Caspase-mediated cleavage of occludin

Stable Identifier
R-HSA-351876
Type
Reaction [transition]
Species
Homo sapiens
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Following iinduction of apoptosis in epithelial cells, tight junction are disrupted. Tight junction proteins, including the the transmembrane protein occludin and the cytoplasmic adaptor proteins ZO-1 and ZO-2 are fragmented by caspase cleavage (Bojarski et al., 2004). Inhibition of caspase-3 prevents cleavage of occludin, implicating caspase-3 as the responsible endopeptidase (Bojarski et al. 2004).

Literature References
PubMed ID Title Journal Year
15054114 The specific fates of tight junction proteins in apoptotic epithelial cells

Bojarski, C, Weiske, J, Schöneberg, T, Schröder, W, Mankertz, J, Schulzke, JD, Florian, P, Fromm, M, Tauber, R, Huber, O

J Cell Sci 2004
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Catalyst Activity
Title
cysteine-type endopeptidase activity of Caspase-3 [cytosol]
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Activity
Orthologous Events
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