Caspase mediated cleavage of vimentin at IDVD (259)

Stable Identifier
R-HSA-350319
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Vimentin is cleaved by several caspases during apoptosis (Morishima et al., 1999, Byun et al., 2001). This clevage disrupts the cytoplasmic network of intermediate filaments and coincides temporally with nuclear fragmentation. Asp259 is recognized and cleaved by caspase-6 (Byun et al., 2001).

Literature References
PubMed ID Title Journal Year
11423904 Caspase cleavage of vimentin disrupts intermediate filaments and promotes apoptosis

Byun, Y, Chen, F, Chang, R, Trivedi, M, Green, KJ, Cryns, VL

Cell Death Differ 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of active caspase-8 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created