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Caspase-mediated cleavage of cytoskeletal proteins
Stable Identifier
R-HSA-264870
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Apoptotic execution phase (Homo sapiens)
Apoptotic cleavage of cellular proteins (Homo sapiens)
Caspase-mediated cleavage of cytoskeletal proteins (Homo sapiens)
General
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Caspase-mediated cleavage of a number of proteins in the cortical actin network ( ) microfilament system and others involved in maintenance of the cytoskeletal architecture (vimentin, or Gas2 and plectin) may directly contribute to apoptotic changes in cell shape.
Literature References
PubMed ID
Title
Journal
Year
17254298
SVM-based prediction of caspase substrate cleavage sites
Tan, TW
,
Ranganathan, S
,
Wee, LJ
BMC Bioinformatics
2006
12655297
Many cuts to ruin: a comprehensive update of caspase substrates
Janicke, RU
,
Schulze-Osthoff, K
,
Fischer, U
Cell Death Differ
2003
17599937
CASVM: web server for SVM-based prediction of caspase substrates cleavage sites
Tan, TW
,
Ranganathan, S
,
Wee, LJ
Bioinformatics
2007
Participants
Events
Caspase-mediated cleavage of alpha adducin
(Homo sapiens)
Caspase mediated cleavage of alpha-II-Fodrin
(Homo sapiens)
Caspase-mediated cleavage of GAS2
(Homo sapiens)
Caspase mediated cleavage of HIP-55
(Homo sapiens)
Caspase-mediated cleavage of vimentin at DSVD (85)
(Homo sapiens)
Caspase mediated cleavage of vimentin at IDVD (259)
(Homo sapiens)
Caspase-mediated cleavage of vimentin at TNLD (429)
(Homo sapiens)
Caspase-mediated cleavage of gelsolin
(Homo sapiens)
Caspase-mediated cleavage of plectin-1
(Homo sapiens)
Caspase-mediated cleavage of Tau
(Homo sapiens)
Participates
as an event of
Apoptotic cleavage of cellular proteins (Homo sapiens)
Orthologous Events
Caspase-mediated cleavage of cytoskeletal proteins (Bos taurus)
Caspase-mediated cleavage of cytoskeletal proteins (Caenorhabditis elegans)
Caspase-mediated cleavage of cytoskeletal proteins (Canis familiaris)
Caspase-mediated cleavage of cytoskeletal proteins (Danio rerio)
Caspase-mediated cleavage of cytoskeletal proteins (Drosophila melanogaster)
Caspase-mediated cleavage of cytoskeletal proteins (Gallus gallus)
Caspase-mediated cleavage of cytoskeletal proteins (Mus musculus)
Caspase-mediated cleavage of cytoskeletal proteins (Rattus norvegicus)
Caspase-mediated cleavage of cytoskeletal proteins (Sus scrofa)
Caspase-mediated cleavage of cytoskeletal proteins (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000407
,
BIOMD0000000243
,
BIOMD0000000220
Authored
Schulze-Osthoff, K (2007-09-03)
Reviewed
Ranganathan, S (2008-06-11)
Created
Matthews, L (2008-04-14)
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