Reactome | Caspase-mediated cleavage of cytoskeletal proteins

Caspase-mediated cleavage of cytoskeletal proteins

Stable Identifier

R-HSA-264870

Type

Pathway

Species

Homo sapiens

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Caspase-mediated cleavage of cytoskeletal proteins

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Caspase-mediated cleavage of a number of proteins in the cortical actin network ( ) microfilament system and others involved in maintenance of the cytoskeletal architecture (vimentin, or Gas2 and plectin) may directly contribute to apoptotic changes in cell shape.

Literature References

PubMed ID	Title	Journal	Year
12655297	Many cuts to ruin: a comprehensive update of caspase substrates Fischer, U, Janicke, RU, Schulze-Osthoff, K	Cell Death Differ	2003
17254298	SVM-based prediction of caspase substrate cleavage sites Wee, LJ, Tan, TW, Ranganathan, S	BMC Bioinformatics	2006
17599937	CASVM: web server for SVM-based prediction of caspase substrates cleavage sites Wee, LJ, Tan, TW, Ranganathan, S	Bioinformatics	2007