Reactome | Ub-121-HIST1H2BM [nucleoplasm]

Ub-121-HIST1H2BM [nucleoplasm]

Stable Identifier

R-HSA-3364027

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone H2B.e K121ub

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by WNT (Homo sapiens)
  - TCF dependent signaling in response to WNT (Homo sapiens)
    - Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
      - MLL2 complex trimethylates H3K4 at the MYC gene (Homo sapiens)
        
        MYC gene: H2B K121ub nucleosome [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H2BK121ub [nucleoplasm] (Homo sapiens)
        
        Histone H2B K121ub [nucleoplasm] (Homo sapiens)
        
        Ub-121-HIST1H2BM [nucleoplasm] (Homo sapiens)
        
        MYC gene:H2B K121ub H3K4me3 nucleosome [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H2BK121ub and H3K4me3 [nucleoplasm] (Homo sapiens)
        
        Histone H2B K121ub [nucleoplasm] (Homo sapiens)
        
        Ub-121-HIST1H2BM [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99879 H2BC14

Gene Names

H2BC14, H2BFE, HIST1H2BM

Chain

initiator methionine:1, chain:2-126

Reference Genes

BioGPS Gene:8342 H2BC14

COSMIC - genes:HIST1H2BM H2BC14

CTD Gene:8342 H2BC14

dbSNP Gene:8342 H2BC14

ENSEMBL:ENSG00000273703 H2BC14

HGNC:4750 H2BC14

KEGG:hsa:8342 H2BC14

Monarch:8342 H2BC14

NCBI Gene:8342 H2BC14

OMIM:602802 H2BC14

UCSC:Q99879 H2BC14

Reference Transcript

RefSeq:NM_003521.3 H2BC14

Other Identifiers

11733740_at

17005865

208515_PM_at

208515_at

2900060

2900061

31528_f_at

8117594

8342

ADDON002868.hg

A_24_P3783

GO:0000786

GO:0003677

GO:0005198

GO:0005634

GO:0005654

GO:0005694

GO:0005829

GO:0006325

GO:0006334

GO:0030527

GO:0046982

GO:0065003

GO:0070062

HMNXSV003032132

ILMN_1736820

PH_hs_0032040

TC06000265.hg

g4504262_3p_at

Participates

as a candidate of

Histone H2B K121ub [nucleoplasm] (Homo sapiens)

Other forms of this molecule

Ub-HIST1H2BM [nucleoplasm]

AcK-HIST1H2BM [nucleoplasm]

AcK16-HIST1H2BM [nucleoplasm]

AcK6-HIST1H2BM [nucleoplasm]

AcK21-HIST1H2BM [nucleoplasm]

AcK13-HIST1H2BM [nucleoplasm]

HIST1H2BM [extracellular region]

HIST1H2BM [nucleoplasm]

Inferred To

H2B [nucleoplasm] (Bos taurus)

Ub-121-HIST1H2BL [nucleoplasm] (Bos taurus)

Ub-121-HIST1H2BC [nucleoplasm] (Bos taurus)

h2bc11 [nucleoplasm] (Xenopus tropicalis)

Homologues of Ub-121-HIST1H2BL [nucleoplasm] (Bos taurus)

LOC100498553 [nucleoplasm] (Xenopus tropicalis)

LOC116411635 [nucleoplasm] (Xenopus tropicalis)

LOC119877882 [nucleoplasm] (Canis familiaris)

LOC100486870 [nucleoplasm] (Xenopus tropicalis)

H2Bv3 [nucleoplasm] (Dictyostelium discoideum)

H2BC5 [nucleoplasm] (Sus scrofa)

hist2h2l [nucleoplasm] (Danio rerio)

Homologues of Ub-121-HIST3H2BB [nucleoplasm] (Xenopus tropicalis)

h2bc21 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

ubiquitinylated lysine at 121

Coordinate

121

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_003512.1

ENSEMBL

ENSG00000273703, ENSP00000477907, ENST00000621112

OpenTargets

ENSG00000273703

GeneCards

H2BC14

HPA

ENSG00000273703-H2BC14

PRO

Q99879

Pharos - Targets

Q99879

GlyGen

Q99879

PDB

9D3K, 9D3P, 9D3T, 9D3N, 9D3L, 9D3Q, 9D3S, 9D3M, 9D3O

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