Reactome | Ub-121-HIST1H2BK [nucleoplasm]

Ub-121-HIST1H2BK [nucleoplasm]

Stable Identifier

R-HSA-3364019

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone H2B K K121ub

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by WNT (Homo sapiens)
  - TCF dependent signaling in response to WNT (Homo sapiens)
    - Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
      - SET1 complex trimethylates H3K4 at the MYC gene (Homo sapiens)
        
        MYC gene: H2B K121ub nucleosome [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H2BK121ub [nucleoplasm] (Homo sapiens)
        
        Histone H2B K121ub [nucleoplasm] (Homo sapiens)
        
        Ub-121-HIST1H2BK [nucleoplasm] (Homo sapiens)
        
        MYC gene:H2B K121ub H3K4me3 nucleosome [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H2BK121ub and H3K4me3 [nucleoplasm] (Homo sapiens)
        
        Histone H2B K121ub [nucleoplasm] (Homo sapiens)
        
        Ub-121-HIST1H2BK [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60814 H2BC12

Gene Names

H2BC12, H2BFT, HIRIP1, HIST1H2BK

Chain

initiator methionine:1, chain:2-126

Reference Genes

BioGPS Gene:85236 H2BC12

CTD Gene:85236 H2BC12

dbSNP Gene:85236 H2BC12

ENSEMBL:ENSG00000197903.8 H2BC12

HGNC:13954 H2BC12

KEGG Gene (Homo sapiens):85236 H2BC12

Monarch:85236 H2BC12

NCBI Gene:85236 H2BC12

OMIM:615045 H2BC12

UCSC:O60814 H2BC12

Reference Transcript

Other Identifiers

17016457

208579_PM_x_at

208579_x_at

2946721

2946722

35576_f_at

36347_f_at

3923212

3923213

8068898

85236

A_33_P3229083

GE553273

GO:0000786

GO:0002227

GO:0002376

GO:0003674

GO:0003677

GO:0005198

GO:0005515

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006325

GO:0006334

GO:0019731

GO:0030527

GO:0031640

GO:0032991

GO:0042742

GO:0043226

GO:0046982

GO:0050829

GO:0050830

GO:0061844

GO:0065003

GO:0098542

HMNXSV003040333

ILMN_1813314

PH_hs_0037388

TC06001387.hg

TC06001388.hg

TC21000211.hg

TC21000762.hg

Participates

as a candidate of

Histone H2B K121ub [nucleoplasm] (Homo sapiens)

Other forms of this molecule

HIST1H2BK [extracellular region]

Ub-HIST1H2BK [nucleoplasm]

AcK-HIST1H2BK [nucleoplasm]

AcK6-HIST1H2BK [nucleoplasm]

HIST1H2BK [nucleoplasm]

AcK21-HIST1H2BK [nucleoplasm]

AcK13-HIST1H2BK [nucleoplasm]

AcK16-HIST1H2BK [nucleoplasm]

Inferred To

LOC100498553 [nucleoplasm] (Xenopus tropicalis)

hist1h2ba [nucleoplasm] (Danio rerio)

LOC116411635 [nucleoplasm] (Xenopus tropicalis)

h2bc14 [nucleoplasm] (Xenopus tropicalis)

Homologues of Ub-121-HIST1H2BK [nucleoplasm] (Danio rerio)

Homologues of Ub-121-HIST1H2BK [nucleoplasm] (Xenopus tropicalis)

H2BC18 [nucleoplasm] (Bos taurus)

hist2h2l [nucleoplasm] (Danio rerio)

LOC570661 [nucleoplasm] (Danio rerio)

hist2h2bf [nucleoplasm] (Xenopus tropicalis)

Ub-121-HIST1H2BK [nucleoplasm] (Canis familiaris)

Ub-121-HIST1H2BK [nucleoplasm] (Danio rerio)

Ub-121-HIST1H2BK [nucleoplasm] (Xenopus tropicalis)

H2bc12 [nucleoplasm] (Rattus norvegicus)

h2bc21 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

ubiquitinylated lysine at 121

Coordinate

121

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001299582.1, NP_542160.1

OpenTargets

ENSG00000197903

GeneCards

O60814

HPA

ENSG00000197903-H2BC12

Ensembl

ENSG00000197903, ENST00000356950, ENSP00000349430

PRO

O60814

Pharos - Targets

O60814

PDB

7BWD, 6LE9, 6T79, 7JZV, 6V92, 7V99, 6T7A, 6T7D, 6KE9, 6T7B, 6Y5D, 7DBP, 6T7C, 6L9H, 2CV5