Autoglucosylation of GYG1 complexed with GYS1-a

Stable Identifier
R-HSA-3322025
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
8 UDP-glucose + GYG1 => 8 UDP + oligoGlc-GYG1 (GYS1-a)
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Glycogenin 1 (GYG1) catalyzes its autoglycosylation reaction with UDP-glucose to form oligo (1,4)-alpha-D-glucosyl GYG1 (Moslemi et al. 2010). The oligosaccharide is annotated here as containing four glucose residues. Glycogenin occurs as a homodimer complexed with two molecules of glycogen synthase 1 (GYS1), here in an unphosphorylated (a) form (Roach et al. 2012).

Literature References
PubMed ID Title Journal Year
20357282 Glycogenin-1 deficiency and inactivated priming of glycogen synthesis

Nilsson, J, Oldfors, A, Lindberg, C, Moslemi, AR, Andersson, B, Tajsharghi, H

N. Engl. J. Med. 2010
22248338 Glycogen and its metabolism: some new developments and old themes

Hurley, TD, Roach, PJ, Tagliabracci, VS, DePaoli-Roach, AA

Biochem. J. 2012
Participants
Participates
Catalyst Activity

glycogenin glucosyltransferase activity of GYG1:GYS1-a tetramer [cytosol]

Orthologous Events
Reviewed
Created
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