Reactome | Autoglucosylation of GYG1 complexed with GYS1-a

Autoglucosylation of GYG1 complexed with GYS1-a

Stable Identifier

R-HSA-3322025

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

8 UDP-glucose + GYG1 => 8 UDP + oligoGlc-GYG1 (GYS1-a)

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Autoglucosylation of GYG1 complexed with GYS1-a

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Glycogenin 1 (GYG1) catalyzes its autoglycosylation reaction with UDP-glucose to form oligo (1,4)-alpha-D-glucosyl GYG1 (Moslemi et al. 2010). The oligosaccharide is annotated here as containing four glucose residues. Glycogenin occurs as a homodimer complexed with two molecules of glycogen synthase 1 (GYS1), here in an unphosphorylated (a) form (Roach et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
22248338	Glycogen and its metabolism: some new developments and old themes Roach, PJ, DePaoli-Roach, AA, Hurley, TD, Tagliabracci, VS	Biochem. J.	2012
20357282	Glycogenin-1 deficiency and inactivated priming of glycogen synthesis Moslemi, AR, Lindberg, C, Nilsson, J, Tajsharghi, H, Andersson, B, Oldfors, A	N. Engl. J. Med.	2010