Reactome | TAS2R3 [plasma membrane]

TAS2R3 [plasma membrane]

Stable Identifier

R-HSA-3299621

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Taste receptor type 2 member 3, TA2R3_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R3 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R3 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R3 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
      - T2Rs bind bitter-tasting compounds (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R3 [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R3 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NYW6 TAS2R3

Gene Names

TAS2R3

Chain

chain:1-316

Reference Genes

BioGPS Gene:50831 TAS2R3

COSMIC (genes):TAS2R3 TAS2R3

CTD Gene:50831 TAS2R3

dbSNP Gene:50831 TAS2R3

ENSEMBL:ENSG00000127362 TAS2R3

HGNC:14910 TAS2R3

KEGG Gene (Homo sapiens):50831 TAS2R3

Monarch:50831 TAS2R3

NCBI Gene:50831 TAS2R3

OMIM:604868 TAS2R3

UCSC:Q9NYW6 TAS2R3

Reference Transcript

RefSeq:NM_016943.2 TAS2R3

Other Identifiers

0002370273

11738194_at

17052413

221456_at

3027944

3027945

3027946

50831

8136641

A_14_P110580

GE82159

GO:0001580

GO:0003674

GO:0004930

GO:0005575

GO:0005886

GO:0007165

GO:0007186

GO:0008150

GO:0008527

GO:0016020

GO:0016021

GO:0033038

GO:0050877

GO:0050896

GO:0050909

HMNXSV003024119

ILMN_1718253

PH_hs_0026759

TC07000893.hg

g8394397_3p_at

Participates

as a component of

TAS2R3:ligand [plasma membrane] (Homo sapiens)

as a member of

Inferred To

LOC116407540 [plasma membrane] (Xenopus tropicalis)

t2r9 [plasma membrane] (Xenopus tropicalis)

Tas2r3 [plasma membrane] (Mus musculus)

Tas2r3 [plasma membrane] (Rattus norvegicus)

t2r24 [plasma membrane] (Xenopus tropicalis)

t2r38 [plasma membrane] (Xenopus tropicalis)

LOC101731190 [plasma membrane] (Xenopus tropicalis)

TAS2R7 [plasma membrane] (Gallus gallus)

t2r43 [plasma membrane] (Xenopus tropicalis)

t2r4 [plasma membrane] (Xenopus tropicalis)

tas2r200.1 [plasma membrane] (Danio rerio)

tas2r7 [plasma membrane] (Xenopus tropicalis)

t2r5 [plasma membrane] (Xenopus tropicalis)

tas2r13 [plasma membrane] (Xenopus tropicalis)

TAS2R40 [plasma membrane] (Gallus gallus)

TAS2R3 [plasma membrane] (Bos taurus)

TAS2R3 [plasma membrane] (Canis familiaris)

TAS2R3 [plasma membrane] (Gallus gallus)

TAS2R3 [plasma membrane] (Sus scrofa)

TAS2R3 [plasma membrane] (Xenopus tropicalis)

Homologues of TAS2R3 [plasma membrane] (Danio rerio)

Homologues of TAS2R3 [plasma membrane] (Gallus gallus)

Homologues of TAS2R3 [plasma membrane] (Xenopus tropicalis)

LOC100494566 [plasma membrane] (Xenopus tropicalis)

t2r15 [plasma membrane] (Xenopus tropicalis)

tas2r4 [plasma membrane] (Xenopus tropicalis)

tas2r200.2 [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_058639.1

Guide to Pharmacology - Targets

660

OpenTargets

ENSG00000127362

HPA

ENSG00000127362-TAS2R3

GeneCards

Q9NYW6

Ensembl

ENST00000247879, ENSP00000247879, ENSG00000127362

PRO

Q9NYW6

Pharos - Targets

Q9NYW6

GlyGen

Q9NYW6

HMDB Protein

HMDBP08041