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TAS2R50 [plasma membrane]
Stable Identifier
R-HSA-3299619
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Taste receptor type 2 member 50, T2R50_HUMAN
Locations in the PathwayBrowser
Expand all
Sensory Perception (Homo sapiens)
Sensory perception of taste (Homo sapiens)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Homo sapiens)
Bitter compound binds bitter taste receptor (TAS2R) (Homo sapiens)
TAS2R:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS2R (non-orphan) [plasma membrane] (Homo sapiens)
TAS2R50 [plasma membrane] (Homo sapiens)
TAS2R:ligand:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS2R (non-orphan):ligand [plasma membrane] (Homo sapiens)
TAS2R50:ligand [plasma membrane] (Homo sapiens)
TAS2R50 [plasma membrane] (Homo sapiens)
GNAT3 exchanges GDP for GTP in TAS2R:bitter compound:GNAT3:GDP:GNB1,3:GNG13 (Homo sapiens)
TAS2R:ligand:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS2R (non-orphan):ligand [plasma membrane] (Homo sapiens)
TAS2R50:ligand [plasma membrane] (Homo sapiens)
TAS2R50 [plasma membrane] (Homo sapiens)
TAS2R:ligand:GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS2R (non-orphan):ligand [plasma membrane] (Homo sapiens)
TAS2R50:ligand [plasma membrane] (Homo sapiens)
TAS2R50 [plasma membrane] (Homo sapiens)
TAS2R:bitter compound:GNAT3:GTP:GNB1,3:GNG13 dissociates yielding (Homo sapiens)
TAS2R (non-orphan):ligand [plasma membrane] (Homo sapiens)
TAS2R50:ligand [plasma membrane] (Homo sapiens)
TAS2R50 [plasma membrane] (Homo sapiens)
TAS2R:ligand:GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS2R (non-orphan):ligand [plasma membrane] (Homo sapiens)
TAS2R50:ligand [plasma membrane] (Homo sapiens)
TAS2R50 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R50 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R50 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R50 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R50 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R50 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R50 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
T2Rs bind bitter-tasting compounds (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R50 [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R50 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P59544 TAS2R50
Gene Names
TAS2R50
Chain
chain:1-299
Reference Genes
BioGPS Gene:259296 TAS2R50
COSMIC (genes):TAS2R50 TAS2R50
CTD Gene:259296 TAS2R50
dbSNP Gene:259296 TAS2R50
ENSEMBL:ENSG00000212126 TAS2R50
ENSEMBL_homo_sapiens_GENE:ENSG00000212126.3 TAS2R50
ENSEMBL_homo_sapiens_GENE:ENSG00000273431.1 TAS2R50
ENSEMBL_homo_sapiens_GENE:ENSG00000276167.1 TAS2R50
HGNC:18882 TAS2R50
KEGG Gene (Homo sapiens):259296 TAS2R50
Monarch:259296 TAS2R50
NCBI Gene:259296 TAS2R50
OMIM:609627 TAS2R50
UCSC:P59544 TAS2R50
Reference Transcript
RefSeq:NM_176890.2 TAS2R50
Other Identifiers
11738919_at
1553561_PM_at
1553561_at
16761507
259296
3444473
7961281
A_23_P347029
GE469866
GO:0001580
GO:0004930
GO:0005886
GO:0007165
GO:0007186
GO:0016020
GO:0023052
GO:0033038
GO:0050877
GO:0050896
GO:0050909
GO:0060089
HMNXSV003029589
Hs2Affx.1.39.S1_3p_at
ILMN_1802731
TC12001236.hg
Participates
as a member of
TAS2R (non-orphan) [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
as a component of
TAS2R50:ligand [plasma membrane] (Homo sapiens)
Inferred To
TAS2R46 [plasma membrane]
(Bos taurus)
Tas2r120 [plasma membrane]
(Mus musculus)
Tas2r120 [plasma membrane]
(Rattus norvegicus)
Tas2r136 [plasma membrane]
(Mus musculus)
Tas2r136 [plasma membrane]
(Rattus norvegicus)
t2r14 [plasma membrane]
(Xenopus tropicalis)
CAFA-T2R43 [plasma membrane]
(Canis familiaris)
t2r2 [plasma membrane]
(Xenopus tropicalis)
Homologues of TAS2R19 [plasma membrane]
(Bos taurus)
Homologues of TAS2R19 [plasma membrane]
(Canis familiaris)
Homologues of TAS2R19 [plasma membrane]
(Danio rerio)
Homologues of TAS2R19 [plasma membrane]
(Gallus gallus)
Homologues of TAS2R19 [plasma membrane]
(Mus musculus)
Homologues of TAS2R19 [plasma membrane]
(Rattus norvegicus)
Homologues of TAS2R19 [plasma membrane]
(Xenopus tropicalis)
LOC100154902 [plasma membrane]
(Sus scrofa)
t2r3 [plasma membrane]
(Xenopus tropicalis)
TAS2R7 [plasma membrane]
(Gallus gallus)
tas2r200.1 [plasma membrane]
(Danio rerio)
tas2r7 [plasma membrane]
(Xenopus tropicalis)
TAS2R40 [plasma membrane]
(Gallus gallus)
LOC100682759 [plasma membrane]
(Canis familiaris)
t2r15 [plasma membrane]
(Xenopus tropicalis)
tas2r4 [plasma membrane]
(Xenopus tropicalis)
LOC782957 [plasma membrane]
(Bos taurus)
TAS2R19 [plasma membrane]
(Bos taurus)
tas2r200.2 [plasma membrane]
(Danio rerio)
LOC101747503 [plasma membrane]
(Gallus gallus)
Cross References
RefSeq
NP_795371.2
Guide to Pharmacology - Targets
677
OpenTargets
ENSG00000212126
HPA
ENSG00000212126-TAS2R50
GeneCards
P59544
Ensembl
ENSP00000458551
,
ENSP00000479785
,
ENSP00000424040
,
ENSG00000273431
,
ENSG00000212126
,
ENSG00000276167
,
ENST00000613831
,
ENST00000575654
,
ENST00000506868
PRO
P59544
Pharos - Targets
P59544
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