Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
TAS2R45 [plasma membrane]
Stable Identifier
R-HSA-3299603
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Taste receptor type 2 member 45, T2R45_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R45 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R45 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R45 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R45 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R45 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R45 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
T2Rs bind bitter-tasting compounds (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R45 [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R45 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P59539 TAS2R45
Gene Names
TAS2R45, GPR59
Chain
chain:1-299
Reference Genes
HGNC:18876 TAS2R45
OMIM:613967 TAS2R45
UCSC:P59539 TAS2R45
Participates
as a member of
TAS2Rs [plasma membrane] (Homo sapiens)
Inferred To
TAS2R46 [plasma membrane]
(Bos taurus)
Tas2r120 [plasma membrane]
(Mus musculus)
Tas2r120 [plasma membrane]
(Rattus norvegicus)
Tas2r136 [plasma membrane]
(Mus musculus)
Tas2r136 [plasma membrane]
(Rattus norvegicus)
t2r14 [plasma membrane]
(Xenopus tropicalis)
CAFA-T2R43 [plasma membrane]
(Canis familiaris)
t2r2 [plasma membrane]
(Xenopus tropicalis)
Homologues of TAS2R19 [plasma membrane]
(Bos taurus)
Homologues of TAS2R19 [plasma membrane]
(Canis familiaris)
Homologues of TAS2R19 [plasma membrane]
(Danio rerio)
Homologues of TAS2R19 [plasma membrane]
(Gallus gallus)
Homologues of TAS2R19 [plasma membrane]
(Mus musculus)
Homologues of TAS2R19 [plasma membrane]
(Rattus norvegicus)
Homologues of TAS2R19 [plasma membrane]
(Xenopus tropicalis)
LOC100154902 [plasma membrane]
(Sus scrofa)
t2r3 [plasma membrane]
(Xenopus tropicalis)
TAS2R7 [plasma membrane]
(Gallus gallus)
tas2r200.1 [plasma membrane]
(Danio rerio)
tas2r7 [plasma membrane]
(Xenopus tropicalis)
TAS2R40 [plasma membrane]
(Gallus gallus)
LOC100682759 [plasma membrane]
(Canis familiaris)
t2r15 [plasma membrane]
(Xenopus tropicalis)
tas2r4 [plasma membrane]
(Xenopus tropicalis)
LOC782957 [plasma membrane]
(Bos taurus)
TAS2R19 [plasma membrane]
(Bos taurus)
tas2r200.2 [plasma membrane]
(Danio rerio)
LOC101747503 [plasma membrane]
(Gallus gallus)
Cross References
Guide to Pharmacology - Targets
2828
PRO
P59539
Pharos - Targets
P59539
GlyGen
P59539
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
