Reactome | WNT ligands traffic to the plasma membrane

WNT ligands traffic to the plasma membrane

Stable Identifier

R-HSA-3247844

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

Golgi membrane, plasma membrane

ReviewStatus

5/5

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WNT ligands traffic to the plasma membrane

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WLS accompanies WNT through the secretory pathway to the cell surface, where the ligand is released into the extracellular space (Bänziger et al, 2006; Bartscherer et al, 2006; Goodman et al, 2006).

Literature References

PubMed ID	Title	Journal	Year
16678096	Secretion of Wnt ligands requires Evi, a conserved transmembrane protein Bartscherer, K, Pelte, N, Ingelfinger, D, Boutros, M	Cell	2006
17108000	Sprinter: a novel transmembrane protein required for Wg secretion and signaling Goodman, RM, Thombre, S, Firtina, Z, Gray, D, Betts, D, Roebuck, J, Spana, EP, Selva, EM	Development	2006
16678095	Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells Bänziger, C, Soldini, D, Schütt, C, Zipperlen, P, Hausmann, G, Basler, K	Cell	2006