WNT ligands traffic to the plasma membrane

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

WLS accompanies WNT through the secretory pathway to the cell surface, where the ligand is released into the extracellular space (Bänziger et al, 2006; Bartscherer et al, 2006; Goodman et al, 2006).

Literature References
PubMed ID Title Journal Year
17108000 Sprinter: a novel transmembrane protein required for Wg secretion and signaling

Goodman, RM, Thombre, S, Firtina, Z, Gray, D, Betts, D, Roebuck, J, Spana, EP, Selva, EM

Development 2006
16678096 Secretion of Wnt ligands requires Evi, a conserved transmembrane protein

Bartscherer, K, Pelte, N, Ingelfinger, D, Boutros, M

Cell 2006
16678095 Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells

Bänziger, C, Soldini, D, Schütt, C, Zipperlen, P, Hausmann, G, Basler, K

Cell 2006
Participant Of
Orthologous Events
Cite Us!