secretion of WNT ligands

Stable Identifier
R-HSA-3247843
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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Vacuolar acidification is required but not sufficient for the release of WNT ligands from WLS at the cell surface. V-ATPase inhibitors cause the accumulation of WLS-WNT complexes both within the cell and at the plasma membrane (Coombs et al, 2010).
Once in the extracellular space, the lipid-modified WNT ligand must be shielded to allow the morphogen to diffuse away from the plasma membrane. Possible mechanisms include interaction with HSPGs, exosomes, multimerization or incorporation into lipoprotein particles (reviewed in Eaton, 2006; Port and Basler, 2010).

Literature References
PubMed ID Title Journal Year
20477987 Wnt trafficking: new insights into Wnt maturation, secretion and spreading

Port, F, Basler, K

Traffic 2010
20826466 WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification

Coombs, GS, Yu, J, Canning, CA, Veltri, CA, Covey, TM, Cheong, JK, Utomo, V, Banerjee, N, Zhang, ZH, Jadulco, RC, Concepcion, GP, Bugni, TS, Harper, MK, Mihalek, I, Jones, CM, Ireland, CM, Virshup, DM

J. Cell. Sci. 2010
16364628 Release and trafficking of lipid-linked morphogens

Eaton, S

Curr. Opin. Genet. Dev. 2006
Participants
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