Reactome | secretion of WNT ligands

secretion of WNT ligands

Stable Identifier

R-HSA-3247843

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Vacuolar acidification is required but not sufficient for the release of WNT ligands from WLS at the cell surface. V-ATPase inhibitors cause the accumulation of WLS-WNT complexes both within the cell and at the plasma membrane (Coombs et al, 2010).
Once in the extracellular space, the lipid-modified WNT ligand must be shielded to allow the morphogen to diffuse away from the plasma membrane. Possible mechanisms include interaction with HSPGs, exosomes, multimerization or incorporation into lipoprotein particles (reviewed in Eaton, 2006; Port and Basler, 2010).

Literature References

PubMed ID	Title	Journal	Year
20826466	WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification Coombs, GS, Utomo, V, Jones, CM, Bugni, TS, Cheong, JK, Zhang, ZH, Harper, MK, Virshup, DM, Veltri, CA, Jadulco, RC, Banerjee, N, Concepcion, GP, Yu, J, Mihalek, I, Canning, CA, Ireland, CM, Covey, TM	J. Cell. Sci.	2010
20477987	Wnt trafficking: new insights into Wnt maturation, secretion and spreading Port, F, Basler, K	Traffic	2010
16364628	Release and trafficking of lipid-linked morphogens Eaton, S	Curr. Opin. Genet. Dev.	2006