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monoSUMO1-K21-TFAP2B [nucleoplasm]
Stable Identifier
R-HSA-3234107
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
SUMO1 N-glycyl-lys21 TFAP2B, Transcription factor AP-2-beta, AP2B_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (Homo sapiens)
Negative regulation of activity of TFAP2 (AP-2) family transcription factors (Homo sapiens)
SUMOylation of TFAP2B with SUMO1 (Homo sapiens)
SUMO1:TFAP2B homodimer [nucleoplasm] (Homo sapiens)
monoSUMO1-K21-TFAP2B [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of transcription factors (Homo sapiens)
SUMOylation of TFAP2B with SUMO1 (Homo sapiens)
SUMO1:TFAP2B homodimer [nucleoplasm] (Homo sapiens)
monoSUMO1-K21-TFAP2B [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92481 TFAP2B
Gene Names
TFAP2B
Chain
chain:1-460
Reference Genes
BioGPS Gene:7021 TFAP2B
COSMIC (genes):TFAP2B TFAP2B
CTD Gene:7021 TFAP2B
dbSNP Gene:7021 TFAP2B
ENSEMBL:ENSG00000008196 TFAP2B
ENSEMBL_homo_sapiens_GENE:ENSG00000008196.13 TFAP2B
HGNC:11743 TFAP2B
KEGG Gene (Homo sapiens):7021 TFAP2B
Monarch:7021 TFAP2B
NCBI Gene:7021 TFAP2B
OMIM:601601 TFAP2B
UCSC:Q92481 TFAP2B
Reference Transcript
RefSeq:XM_011514837.2 TFAP2B
RefSeq:NM_003221.3 TFAP2B
Other Identifiers
11733305_a_at
11733306_a_at
11733307_at
1553394_PM_a_at
1553394_a_at
17009545
214451_PM_at
214451_at
2909951
2909955
2909956
2909962
2909967
2909968
2909969
2909973
2909974
2909976
2909977
2909978
2909979
2909980
2909981
2909982
2909983
2909984
2909985
2909986
2909987
2909988
2909989
2909990
39668_at
7021
8120194
A_24_P20954
A_33_P3317163
GE60178
GO:0000122
GO:0000785
GO:0000977
GO:0000978
GO:0000981
GO:0000987
GO:0001228
GO:0001822
GO:0003677
GO:0003682
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005975
GO:0006006
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0007423
GO:0008284
GO:0008285
GO:0009410
GO:0010467
GO:0010842
GO:0012501
GO:0023052
GO:0030154
GO:0030510
GO:0035136
GO:0035137
GO:0035909
GO:0042127
GO:0042803
GO:0043066
GO:0043226
GO:0043524
GO:0043525
GO:0043565
GO:0043588
GO:0045444
GO:0045595
GO:0045892
GO:0045893
GO:0045944
GO:0046982
GO:0048485
GO:0048745
GO:0048856
GO:0050796
GO:0051402
GO:0072017
GO:0072044
GO:0072210
GO:0097070
GO:0140110
GO:1990837
HMNXSV003046942
Hs.33102.0.S1_3p_at
Hs.33102.1.S1_3p_s_at
Hs2.33102.1.S1_3p_s_at
ILMN_1758404
ILMN_1853592
PH_hs_0002784
TC06000647.hg
Y09912_rna1_at
Participates
as a component of
SUMO1:TFAP2B homodimer [nucleoplasm] (Homo sapiens)
Other forms of this molecule
TFAP2B [nucleoplasm]
Modified Residues
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 21
Coordinate
21
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
NP_003212.2
,
XP_011513139.1
OpenTargets
ENSG00000008196
GeneCards
Q92481
HPA
ENSG00000008196-TFAP2B
Ensembl
ENSG00000008196
,
ENST00000393655
,
ENSP00000377265
PRO
Q92481
Pharos - Targets
Q92481
Orphanet
15601
PDB
8J0Q
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.556
3
UniProt:Q8TAP4-4 LMO3
0.556
3
UniProt:Q15047-2 SETDB1
0.556
3
UniProt:Q92993 KAT5
1
KAT5 [nucleoplasm]
(R-HSA-3321979)
0.556
3
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