Reactome | PRC1.4 [nucleoplasm]

PRC1.4

Stable Identifier

R-HSA-3229073

Type

Complex

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
        
        RUNX1 binds PRC1 complexes (Homo sapiens)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        PRC1.4 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        PRC1.4 [nucleoplasm] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
22325352	PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes	Mol. Cell	2012
28007606	Compositional and functional diversity of canonical PRC1 complexes in mammals	Biochim. Biophys. Acta	2017

Participants

components

Participant Of

hasCandidate

input

PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter

hasComponent

CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm]

Inferred To

PRC1 complex [nucleoplasm] (Taeniopygia guttata)

PRC1.4 [nucleoplasm] (Bos taurus)

PRC1.4 [nucleoplasm] (Canis familiaris)

PRC1.4 [nucleoplasm] (Danio rerio)

PRC1.4 [nucleoplasm] (Drosophila melanogaster)

PRC1.4 [nucleoplasm] (Gallus gallus)

PRC1.4 [nucleoplasm] (Mus musculus)

PRC1.4 [nucleoplasm] (Rattus norvegicus)

PRC1.4 [nucleoplasm] (Sus scrofa)

PRC1.4 [nucleoplasm] (Xenopus tropicalis)

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