SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1

Stable Identifier
Reaction [transition]
Homo sapiens
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The NSMCE2 (NSE2, MMS21) subunit of the SMC5/6 complex SUMOylates the RAD21 and STAG2 subunits of cohesin with SUMO1 (Potts et al. 2006 supplementary data, reviewed in Stephan et al 2011). RAD21 (SCC1) is SUMOylated at several lysines (Wu et al. 2012). SUMOylation of RAD21 occurs during DNA damage repair and is necessary for sister chromatid recombination (Wu et al. 2012).

Literature References
PubMed ID Title Journal Year
16810316 Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks

Potts, PR, Porteus, MH, Yu, H

EMBO J. 2006
22751501 Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl

Zeng, W, Potts, PR, Yokomori, K, Ji, Z, Yu, H, Wu, N, Kong, X

Genes Dev. 2012
21550342 The Nse2/Mms21 SUMO ligase of the Smc5/6 complex in the maintenance of genome stability

Stephan, AK, Kliszczak, M, Morrison, CG

FEBS Lett. 2011
Catalyst Activity

SUMO transferase activity of SMC5-SMC6 Complex [nucleoplasm]

Orthologous Events
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