Reactome | SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1

SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1

Stable Identifier

R-HSA-3108212

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1

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The NSMCE2 (NSE2, MMS21) subunit of the SMC5/6 complex SUMOylates the RAD21 and STAG2 subunits of cohesin with SUMO1 (Potts et al. 2006 supplementary data, reviewed in Stephan et al 2011). RAD21 (SCC1) is SUMOylated at several lysines (Wu et al. 2012). SUMOylation of RAD21 occurs during DNA damage repair and is necessary for sister chromatid recombination (Wu et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
16810316	Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks Potts, PR, Porteus, MH, Yu, H	EMBO J.	2006
22751501	Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl Zeng, W, Potts, PR, Yokomori, K, Ji, Z, Yu, H, Wu, N, Kong, X	Genes Dev.	2012
21550342	The Nse2/Mms21 SUMO ligase of the Smc5/6 complex in the maintenance of genome stability Stephan, AK, Kliszczak, M, Morrison, CG	FEBS Lett.	2011