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HDAC9 [nucleoplasm]
Stable Identifier
R-HSA-3004554
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Histone deacetylase 9, HDAC9_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Differentiation of T cells (Homo sapiens)
Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells) (Homo sapiens)
STAT6, NFATC2 (NFAT1), and NICD1,2 bind the GATA3 gene and cause displacement of repressor complexes (PRC1, RBPJ:NCOR) by activator complexes (MLL1, RBPJ:NICD1,2) (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC9 [nucleoplasm] (Homo sapiens)
PRC1:RBPJ:NCOR:GATA3 gene [nucleoplasm] (Homo sapiens)
RBPJ:NCOR corepressor complex [nucleoplasm] (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC9 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by NOTCH1 in Cancer (Homo sapiens)
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (Homo sapiens)
NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) (Homo sapiens)
NCOR:HDAC:TBL1 [nucleoplasm] (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC9 [nucleoplasm] (Homo sapiens)
RBPJ:NCOR corepressor complex [nucleoplasm] (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC9 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH1 PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 PEST Domain Mutants (Homo sapiens)
NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) (Homo sapiens)
NCOR:HDAC:TBL1 [nucleoplasm] (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC9 [nucleoplasm] (Homo sapiens)
RBPJ:NCOR corepressor complex [nucleoplasm] (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC9 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Notch-HLH transcription pathway (Homo sapiens)
Formation of CSL NCOR corepressor complex (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC9 [nucleoplasm] (Homo sapiens)
RBPJ:NCOR corepressor complex [nucleoplasm] (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC9 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
NOTCH1 Intracellular Domain Regulates Transcription (Homo sapiens)
NICD1 displaces co-repressor complex from RBPJ (CSL) (Homo sapiens)
NCOR:HDAC:TBL1 [nucleoplasm] (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC9 [nucleoplasm] (Homo sapiens)
RBPJ:NCOR corepressor complex [nucleoplasm] (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC9 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UKV0 HDAC9
Gene Names
HDAC9, HDAC7, HDAC7B, HDRP, KIAA0744, MITR
Chain
chain:1-1011
Reference Genes
BioGPS Gene:9734 HDAC9
COSMIC - genes:HDAC7 HDAC7
COSMIC - genes:HDAC9 HDAC9
CTD Gene:9734 HDAC9
dbSNP Gene:9734 HDAC9
ENSEMBL:ENSG00000048052 HDAC9
HGNC:14065 HDAC9
KEGG:hsa:9734 HDAC9
Monarch:9734 HDAC9
NCBI Gene:9734 HDAC9
OMIM:606543 HDAC9
UCSC:Q9UKV0 HDAC9
Reference Transcript
RefSeq:NM_001321870.1 HDAC9
RefSeq:NM_014707.4 HDAC9
RefSeq:NM_001321885.1 HDAC9
RefSeq:NM_001321887.1 HDAC9
RefSeq:NM_001321886.1 HDAC9
RefSeq:NM_001204144.3 HDAC9
RefSeq:NM_001321884.1 HDAC9
RefSeq:NM_001321900.2 HDAC9
RefSeq:NM_001321869.1 HDAC9
RefSeq:NM_001321901.1 HDAC9
RefSeq:NM_001321888.1 HDAC9
RefSeq:NM_001204147.3 HDAC9
RefSeq:NM_001321868.1 HDAC9
RefSeq:NM_001204145.3 HDAC9
RefSeq:NM_001321889.1 HDAC9
RefSeq:NM_001321902.1 HDAC9
RefSeq:NM_001204146.2 HDAC9
RefSeq:NM_001204148.3 HDAC9
RefSeq:NM_001321879.1 HDAC9
RefSeq:NM_001321876.1 HDAC9
RefSeq:NM_001321894.1 HDAC9
RefSeq:NM_178425.4 HDAC9
RefSeq:NM_001321871.1 HDAC9
RefSeq:NM_001321896.2 HDAC9
RefSeq:NM_001321898.1 HDAC9
RefSeq:NM_001321895.1 HDAC9
RefSeq:NM_001321878.1 HDAC9
RefSeq:NM_001321872.1 HDAC9
RefSeq:NM_001321890.1 HDAC9
RefSeq:NM_058176.2 HDAC9
RefSeq:NM_001321891.2 HDAC9
RefSeq:NM_001321893.2 HDAC9
RefSeq:NM_001321874.1 HDAC9
RefSeq:NM_001321875.1 HDAC9
RefSeq:NM_178423.3 HDAC9
RefSeq:NM_001321873.1 HDAC9
RefSeq:NM_001321877.2 HDAC9
RefSeq:NM_001321899.1 HDAC9
RefSeq:NM_001321897.2 HDAC9
Participates
as a member of
HDAC [nucleoplasm] (Homo sapiens)
Inferred To
HDAC9 [nucleoplasm]
(Bos taurus)
HDAC9 [nucleoplasm]
(Canis familiaris)
HDAC9 [nucleoplasm]
(Drosophila melanogaster)
HDAC9 [nucleoplasm]
(Rattus norvegicus)
HDAC9 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_848510.1
,
NP_848512.1
,
NP_001308816.1
,
NP_001308815.1
,
NP_001308818.1
,
NP_001308819.1
,
NP_001191073.1
,
NP_001308817.1
,
NP_001308798.1
,
NP_001308813.1
,
NP_001191074.1
,
NP_001308806.1
,
NP_001308799.1
,
NP_001308797.1
,
NP_001308827.1
,
NP_001308808.1
,
NP_001308805.1
,
NP_001308831.1
,
NP_001308807.1
,
NP_001308829.1
,
NP_001191077.1
,
NP_001191075.1
,
NP_001308814.1
,
NP_001191076.1
,
NP_001308828.1
,
NP_001308830.1
,
NP_001308826.1
,
NP_001308804.1
,
NP_001308825.1
,
NP_001308820.1
,
NP_001308824.1
,
NP_001308800.1
,
NP_001308803.1
,
NP_001308802.1
,
NP_001308801.1
,
NP_478056.1
,
NP_001308823.1
,
NP_055522.1
,
NP_001308822.1
ZINC - World Drugs
HDAC9_HUMAN
Guide to Pharmacology - Targets
2620
OpenTargets
ENSG00000048052
ENSEMBL
ENSP00000383912
,
ENST00000432645
,
ENSP00000509161
,
ENSP00000384382
,
ENSP00000408617
,
ENST00000401921
,
ENSG00000048052
,
ENSP00000401669
,
ENST00000524023
,
ENSP00000388568
,
ENST00000417496
,
ENST00000456174
,
ENSP00000384657
,
ENST00000441542
,
ENSP00000395655
,
ENST00000686413
,
ENSP00000430036
,
ENST00000428307
,
ENST00000405010
,
ENSP00000410337
,
ENST00000406451
ZINC - FDA approved
HDAC9_HUMAN
ZINC - Substances
HDAC9_HUMAN
ZINC - Biogenic
HDAC9_HUMAN
ZINC target
Q9UKV0
PRO
Q9UKV0
GlyGen
Q9UKV0
PDB
8Q9R
,
8Q9N
ZINC - Investigational
HDAC9_HUMAN
HPA
ENSG00000048052-HDAC9
GeneCards
HDAC9
Pharos - Targets
Q9UKV0
ZINC - Predictions - Purchasable
HDAC9_HUMAN
HMDB Protein
HMDBP02256
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P41182 BCL6
1
BCL6 [nucleoplasm]
(R-HSA-5223066)
0.564
2
UniProt:Q06413 MEF2C
3
MEF2C [nucleoplasm]
(R-HSA-199938)
p-S396-MEF2C [nucleoplasm]
(R-HSA-199942)
p-T293,T300,S387-MEF2C [nucleoplasm]
(R-HSA-448838)
0.553
3
UniProt:P22415 USF1
2
USF1 [nucleoplasm]
(R-HSA-9023562)
pT153 USF1 [nucleoplasm]
(R-HSA-9855887)
0.462
3
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