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p-S396-MEF2C [nucleoplasm]
Stable Identifier
R-HSA-199942
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Phospho-Myocyte-specific enhancer factor 2C, MEFC_HUMAN, MEF2C
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
p-MEF2 [nucleoplasm] (Homo sapiens)
p-S396-MEF2C [nucleoplasm] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
p-MEF2 [nucleoplasm] (Homo sapiens)
p-S396-MEF2C [nucleoplasm] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
p-MEF2 [nucleoplasm] (Homo sapiens)
p-S396-MEF2C [nucleoplasm] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
p-MEF2 [nucleoplasm] (Homo sapiens)
p-S396-MEF2C [nucleoplasm] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
p-MEF2 [nucleoplasm] (Homo sapiens)
p-S396-MEF2C [nucleoplasm] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
p-MEF2 [nucleoplasm] (Homo sapiens)
p-S396-MEF2C [nucleoplasm] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
p-MEF2 [nucleoplasm] (Homo sapiens)
p-S396-MEF2C [nucleoplasm] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
p-MEF2 [nucleoplasm] (Homo sapiens)
p-S396-MEF2C [nucleoplasm] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
p-MEF2 [nucleoplasm] (Homo sapiens)
p-S396-MEF2C [nucleoplasm] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
p-MEF2 [nucleoplasm] (Homo sapiens)
p-S396-MEF2C [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK5 activates the transcription factor MEF2 (Homo sapiens)
p-MEF2 [nucleoplasm] (Homo sapiens)
p-S396-MEF2C [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q06413 MEF2C
Gene Names
MEF2C
Chain
chain:1-473
Reference Genes
BioGPS Gene:4208 MEF2C
COSMIC (genes):MEF2C MEF2C
CTD Gene:4208 MEF2C
dbSNP Gene:4208 MEF2C
ENSEMBL:ENSG00000081189 MEF2C
HGNC:6996 MEF2C
KEGG:hsa:4208 MEF2C
Monarch:4208 MEF2C
NCBI Gene:4208 MEF2C
OMIM:600662 MEF2C
UCSC:Q06413 MEF2C
Reference Transcript
RefSeq:XM_006714625.3 MEF2C
RefSeq:NM_001193348.1 MEF2C
RefSeq:NM_001193350.1 MEF2C
RefSeq:NM_001131005.2 MEF2C
RefSeq:NM_002397.4 MEF2C
RefSeq:NM_001193347.1 MEF2C
RefSeq:XM_017009480.1 MEF2C
RefSeq:XM_011543400.1 MEF2C
RefSeq:XM_017009481.1 MEF2C
RefSeq:XM_017009476.1 MEF2C
RefSeq:XM_005248511.2 MEF2C
RefSeq:XM_011543396.2 MEF2C
RefSeq:XM_017009477.1 MEF2C
RefSeq:XM_017009478.1 MEF2C
RefSeq:XM_006714619.2 MEF2C
RefSeq:XM_017009479.1 MEF2C
RefSeq:NM_001193349.1 MEF2C
RefSeq:NM_001308002.1 MEF2C
Other Identifiers
11723213_a_at
11723214_a_at
11723215_s_at
11756531_a_at
16997953
207968_PM_s_at
207968_s_at
209199_PM_s_at
209199_s_at
209200_PM_at
209200_at
2866218
2866219
2866220
2866222
2866224
2866226
2866227
2866228
2866229
2866230
2866231
2866232
2866233
2866234
2866235
2866236
2866237
2866238
2866239
2866247
2866248
2866249
2866250
2866254
2866255
2866256
2866260
2866261
2866278
2866279
2866280
2866291
2866292
2866293
2866294
2866295
2866296
2866297
2866300
2866307
2866308
2866309
2866310
2866311
2866312
2866313
2866314
2866315
2866317
2866318
2866330
2866332
3006180
3006182
37710_at
37711_at
37712_g_at
4208
65938_at
7896727
8113039
A_23_P320739
GE57594
GE81151
GO:0000122
GO:0000165
GO:0000785
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0001228
GO:0001568
GO:0001649
GO:0001764
GO:0001782
GO:0001947
GO:0001958
GO:0001974
GO:0002062
GO:0002376
GO:0002467
GO:0002634
GO:0002931
GO:0003138
GO:0003139
GO:0003151
GO:0003185
GO:0003211
GO:0003677
GO:0003680
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006355
GO:0006915
GO:0006959
GO:0007399
GO:0007507
GO:0007517
GO:0007519
GO:0007521
GO:0007611
GO:0010628
GO:0010629
GO:0010694
GO:0012501
GO:0014033
GO:0014902
GO:0016528
GO:0016607
GO:0030154
GO:0030182
GO:0030220
GO:0030279
GO:0030318
GO:0030501
GO:0030890
GO:0032991
GO:0035984
GO:0042100
GO:0042826
GO:0043226
GO:0043231
GO:0043410
GO:0043523
GO:0043524
GO:0043537
GO:0045652
GO:0045663
GO:0045666
GO:0045669
GO:0045893
GO:0045944
GO:0046928
GO:0046982
GO:0046983
GO:0048167
GO:0048513
GO:0048643
GO:0048666
GO:0048667
GO:0048856
GO:0048870
GO:0050853
GO:0050877
GO:0051145
GO:0051963
GO:0051966
GO:0055012
GO:0060025
GO:0060045
GO:0060079
GO:0060998
GO:0061333
GO:0061629
GO:0071222
GO:0071277
GO:0071374
GO:0071466
GO:0071498
GO:0071560
GO:0072102
GO:0072160
GO:0098794
GO:0098989
GO:0098990
GO:0140110
GO:0140297
GO:1904706
GO:1904753
GO:1905563
GO:1990837
GO:2000111
GO:2000727
GO:2000987
GO:2001013
GO:2001016
HMNXSV003051144
Hs.78995.1.A1_3p_a_at
Hs.78995.1.A3_3p_at
ILMN_1742544
L08895_at
PH_hs_0024090
S57212_s_at
TC05001579.hg
g4505146_3p_a_at
p27588
Participates
as a member of
p-MEF2 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
MEF2C [nucleoplasm]
p-T293,T300,S387-MEF2C [nucleoplasm]
Modified Residues
Name
O-phospho-L-serine at 396
Coordinate
396
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001124477.1
,
XP_011541698.1
,
XP_006714682.1
,
XP_016864970.1
,
NP_002388.2
,
XP_011541702.1
,
XP_005248568.1
,
XP_016864966.1
,
NP_001180279.1
,
NP_001180277.1
,
NP_001180278.1
,
NP_001294931.1
,
XP_016864968.1
,
XP_016864965.1
,
XP_016864969.1
,
XP_016864967.1
,
NP_001180276.1
,
XP_006714688.1
ENSEMBL
ENSP00000426665
,
ENSP00000389610
,
ENST00000514028
,
ENSP00000490473
,
ENST00000508569
,
ENST00000628656
,
ENSP00000424606
,
ENSP00000490630
,
ENST00000636998
,
ENSP00000487430
,
ENSP00000487311
,
ENST00000629612
,
ENST00000625674
,
ENSP00000490241
,
ENST00000424173
,
ENST00000514015
,
ENST00000636294
,
ENSP00000486554
,
ENST00000340208
,
ENST00000637732
,
ENST00000437473
,
ENSP00000421925
,
ENST00000504921
,
ENSP00000340874
,
ENSP00000423597
,
ENSP00000396219
OpenTargets
ENSG00000081189
HPA
ENSG00000081189-MEF2C
PRO
Q06413
Pharos - Targets
Q06413
Orphanet
MEF2C
GlyGen
Q06413
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P56524-2 HDAC4
0.556
5
UniProt:Q9UKV0 HDAC9
1
HDAC9 [nucleoplasm]
(R-HSA-3004554)
0.553
3
UniProt:Q9UQL6 HDAC5
1
HDAC5 [nucleoplasm]
(R-HSA-3004533)
0.547
3
UniProt:Q9H1R3 MYLK2
0.544
2
UniProt:Q02078 MEF2A
3
p-T312,T319-MEF2A [nucleoplasm]
(R-HSA-448834)
p-S408-MEF2A [nucleoplasm]
(R-HSA-199909)
MEF2A [nucleoplasm]
(R-HSA-199903)
0.527
3
UniProt:Q13936 CACNA1C
1
CACNA1C [plasma membrane]
(R-HSA-265551)
0.499
4
UniProt:P56524 HDAC4
3
polySUMO2,3-K559-HDAC4 [nucleoplasm]
(R-HSA-4616029)
monoSUMO1-K559-HDAC4 [nucleoplasm]
(R-HSA-4616016)
HDAC4 [nucleoplasm]
(R-HSA-351581)
0.491
2
UniProt:Q9Z2V6
1
HDAC5 [nucleoplasm]
(R-MMU-3004533)
0.488
2
UniProt:Q05086 UBE3A
1
UBE3A [cytosol]
(R-HSA-976028)
0.463
3
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