Reactome | RANBP2 SUMOylates SP100 with SUMO1

RANBP2 SUMOylates SP100 with SUMO1

Stable Identifier

R-HSA-3000399

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm, nuclear envelope

Synonyms

Conjugation of SUMO1 to SP100

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

RANBP2 SUMOylates SP100 with SUMO1 at lysine-297 (Pichler et al. 2002, Tatham et al. 2005). RANBP2 has a binding site for SUMO1 and a binding site for UBE2I (UBC9) which may recruit the SUMO1:UBE2I (SUMO1:UBC9) complex (Tatham et al. 2005). RANBP2 is located on the cytoplasmic filaments of the nuclear pore so that SUMOylation may occur during nuclear import of SP100 (Pichler et al. 2002)

Literature References

PubMed ID	Title	Journal	Year
18691969	Ubc9 sumoylation regulates SUMO target discrimination Sixma, TK, Fish, A, Olsen, JV, Klug, H, Pichler, A, Flotho, A, Johnson, ES, van Dijk, WJ, Mann, M, Knipscheer, P	Mol. Cell	2008
11792325	The nucleoporin RanBP2 has SUMO1 E3 ligase activity Dejean, A, Seeler, JS, Gast, A, Melchior, F, Pichler, A	Cell	2002
15608651	Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection Kim, S, Tatham, MH, Chen, Y, Hay, RT, Jaffray, E, Song, J	Nat. Struct. Mol. Biol.	2005