RANBP2 SUMOylates SP100 with SUMO1

Stable Identifier
Reaction [transition]
Homo sapiens
Conjugation of SUMO1 to SP100
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RANBP2 SUMOylates SP100 with SUMO1 at lysine-297 (Pichler et al. 2002, Tatham et al. 2005). RANBP2 has a binding site for SUMO1 and a binding site for UBE2I (UBC9) which may recruit the SUMO1:UBE2I (SUMO1:UBC9) complex (Tatham et al. 2005). RANBP2 is located on the cytoplasmic filaments of the nuclear pore so that SUMOylation may occur during nuclear import of SP100 (Pichler et al. 2002)

Literature References
PubMed ID Title Journal Year
18691969 Ubc9 sumoylation regulates SUMO target discrimination

Sixma, TK, Fish, A, Olsen, JV, Klug, H, Pichler, A, Flotho, A, Johnson, ES, van Dijk, WJ, Mann, M, Knipscheer, P

Mol. Cell 2008
11792325 The nucleoporin RanBP2 has SUMO1 E3 ligase activity

Dejean, A, Seeler, JS, Gast, A, Melchior, F, Pichler, A

Cell 2002
15608651 Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection

Kim, S, Tatham, MH, Chen, Y, Hay, RT, Jaffray, E, Song, J

Nat. Struct. Mol. Biol. 2005
Catalyst Activity

SUMO transferase activity of Nuclear Pore Complex (NPC) [nuclear envelope]

Orthologous Events
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