RANBP2 SUMOylates SP100 with SUMO2

Stable Identifier
R-HSA-3000348
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm, nuclear envelope
Synonyms
Conjugation of SUMO2 to SP100
ReviewStatus
5/5
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RANBP2 SUMOylates SP100 with SUMO2
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RANBP2 of the nuclear pore complex SUMOylates SP100 with SUMO2 at lysine-297 (Tatham et al. 2005, Hendriks et al. 2014). RANBP2 binds UBE2I (UBC9) to facilitate the transfer of SUMO2 from SUMO2:UBE2I to SP100 (Tatham et al. 2005).
Literature References
PubMed ID Title Journal Year
15608651 Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection

Tatham, MH, Kim, S, Jaffray, E, Song, J, Chen, Y, Hay, RT

Nat. Struct. Mol. Biol. 2005
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner

Hendriks, IA, D'Souza, RC, Yang, B, Verlaan-de Vries, M, Mann, M, Vertegaal, AC

Nat. Struct. Mol. Biol. 2014
Participants
Input
Output
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as an event of
Catalyst Activity

SUMO transferase activity of Nuclear Pore Complex (NPC) [nuclear envelope]

Physical Entity
Nuclear Pore Complex (NPC) [nuclear envelope] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
RANBP2 SUMOylates SP100 with SUMO2 (Danio rerio)
RANBP2 SUMOylates SP100 with SUMO2 (Mus musculus)
RANBP2 SUMOylates SP100 with SUMO2 (Rattus norvegicus)
RANBP2 SUMOylates SP100 with SUMO2 (Sus scrofa)
RANBP2 SUMOylates SP100 with SUMO2 (Xenopus tropicalis)
Authored
May, B  (2013-01-24)
Reviewed
Ferrari, S  (2015-02-21)
Created
May, B  (2013-01-27)
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