PIAS1,4 SUMOylates BRCA1 with SUMO2,3

Stable Identifier
Reaction [transition]
Homo sapiens
Conjugation of SUMO2,3 to BRCA1
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PIAS1,4 SUMOylate BRCA1 with SUMO2,3 (Galanty et al. 2009, Morris et al. 2009, Vialter et al. 2011, Hendriks et al. 2014). More SUMO2,3-BRCA1 than SUMO1-BRCA1 is observed in vivo (Morris et al. 2009, Galanty et al. 2009). SUMOylation with SUMO2,3 increases in response to oxidative stress (Vialter et al. 2011). SUMOylation of BRCA1 increases its ubiquitin ligase activity (Morris et al. 2009).

Literature References
PubMed ID Title Journal Year
20016603 Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

Jackson, SP, Polo, S, Coates, J, Miller, KM, Galanty, Y, Belotserkovskaya, R

Nature 2009
20016594 The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress

Morris, JR, Keppler, M, Solomon, E, Alamshah, A, Kiuchi, T, Galanty, Y, Pangon, L, Densham, R, Ng, T, Butler, L, Boutell, C, Weekes, D

Nature 2009
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner

Yang, B, Hendriks, IA, Verlaan-de Vries, M, Vertegaal, AC, D'Souza, RC, Mann, M

Nat. Struct. Mol. Biol. 2014
21147198 Cell cycle-dependent conjugation of endogenous BRCA1 protein with SUMO-2/3

Stepien, G, Demidem, A, Rio, PG, Morvan, D, Vincent, A, Venezia, ND, Vialter, A

Biochim. Biophys. Acta 2011
Catalyst Activity

SUMO transferase activity of PIAS1,4 [nucleoplasm]

Orthologous Events
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