PIAS1,4 SUMOylate BRCA1 with SUMO2,3 (Galanty et al. 2009, Morris et al. 2009, Vialter et al. 2011, Hendriks et al. 2014). More SUMO2,3-BRCA1 than SUMO1-BRCA1 is observed in vivo (Morris et al. 2009, Galanty et al. 2009). SUMOylation with SUMO2,3 increases in response to oxidative stress (Vialter et al. 2011). SUMOylation of BRCA1 increases its ubiquitin ligase activity (Morris et al. 2009).
Jackson, SP, Polo, S, Coates, J, Miller, KM, Galanty, Y, Belotserkovskaya, R
Morris, JR, Keppler, M, Solomon, E, Alamshah, A, Kiuchi, T, Galanty, Y, Pangon, L, Densham, R, Ng, T, Butler, L, Boutell, C, Weekes, D
Yang, B, Hendriks, IA, Verlaan-de Vries, M, Vertegaal, AC, D'Souza, RC, Mann, M
Stepien, G, Demidem, A, Rio, PG, Morvan, D, Vincent, A, Venezia, ND, Vialter, A
SUMO transferase activity of PIAS1,4 [nucleoplasm]
© 2022 Reactome
