BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins

Stable Identifier
Reaction [binding]
Homo sapiens
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In late anaphase/early telophase, dephosphorylated BANF1 (BAF) accumulates at a specialized region of the separated chromosome mass, close to the spindle. This region is known as the 'core' and is the central region of the assembling nuclear rim. At the 'core', BANF1 (BAF) binds chromatin, LEM-domain proteins of the inner nuclear membrane (EMD i.e. emerin, TMPO i.e. LAP2beta, LEMD3 i.e. MAN1, LEMD2 i.e. LEM2) and lamins, which initiates the reassembly of the nuclear envelope around separated sister chromatids. LEM-domain proteins and lamin A accumulate at the 'core' in a BANF1-dependent manner (Haraguchi et al. 2001, Haraguchi et al. 2008, Asencio et al. 2012).

Literature References
PubMed ID Title Journal Year
18628300 Live cell imaging and electron microscopy reveal dynamic processes of BAF-directed nuclear envelope assembly

Haraguchi, T, Kojidani, T, Koujin, T, Shimi, T, Osakada, H, Mori, C, Yamamoto, A, Hiraoka, Y

J. Cell. Sci. 2008
11792822 BAF is required for emerin assembly into the reforming nuclear envelope

Haraguchi, T, Koujin, T, Segura-Totten, M, Lee, KK, Matsuoka, Y, Yoneda, Y, Wilson, KL, Hiraoka, Y

J. Cell. Sci. 2001
22770216 Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis

Asencio, C, Davidson, IF, Santarella-Mellwig, R, Ly-Hartig, TB, Mall, M, Wallenfang, MR, Mattaj, IW, Gorjánácz, M

Cell 2012
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Orthologous Events