BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins

Stable Identifier
R-HSA-2995376
Type
Reaction [binding]
Species
Homo sapiens
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In late anaphase/early telophase, the separated sister chromatids usually coalesce into a single "chromatin disc". At the surface of the chromatin disc, there is an accumulation of dephosphorylated BANF1 (BAF) (Kaufmann et al. 2016), as well as proteins EMD (emerin), TMPO (LAP2beta), LEMD3 (MAN1), LEMD2 (LEM2) and lamins (Haraguchi et al. 2008, Asencio et al. 2012). Collectively, these interactions promote enclosure of the separated sister chromatids with nuclear membranes (Anderson et al. 2009).

Literature References
PubMed ID Title Journal Year
18628300 Live cell imaging and electron microscopy reveal dynamic processes of BAF-directed nuclear envelope assembly

Haraguchi, T, Kojidani, T, Koujin, T, Shimi, T, Osakada, H, Mori, C, Yamamoto, A, Hiraoka, Y

J. Cell. Sci. 2008
27875273 SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation

Kaufmann, T, Kukolj, E, Brachner, A, Beltzung, E, Bruno, M, Kostrhon, S, Opravil, S, Hudecz, O, Mechtler, K, Warren, G, Slade, D

J. Cell. Sci. 2016
19620630 Recruitment of functionally distinct membrane proteins to chromatin mediates nuclear envelope formation in vivo

Anderson, DJ, Vargas, JD, Hsiao, JP, Hetzer, MW

J. Cell Biol. 2009
22770216 Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis

Asencio, C, Davidson, IF, Santarella-Mellwig, R, Ly-Hartig, TB, Mall, M, Wallenfang, MR, Mattaj, IW, Gorjánácz, M

Cell 2012
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