POU5F1 (OCT4), NANOG bind the CDX2 promoter

Stable Identifier
R-HSA-2972979
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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POU5F1 (OCT4), NANOG bind the CDX2 promoter
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The CDX2 gene is bound by POU5F1 (OCT4) (Boyer et al. 2005, Lister et al. 2009), SOX2 (Lister et al. 2009) and NANOG ( Boyer et al. 2005, Lister et al. 2009) and POU5F1 repress expression of CDX2 (Babaie et al. 2007). CDX2 and T (Brachyury) mediate the differentiation of stem cells induced by BMP (Bernardo et al. 2011).
Literature References
PubMed ID Title Journal Year
19829295 Human DNA methylomes at base resolution show widespread epigenomic differences

Lister, R, Pelizzola, M, Dowen, RH, Hawkins, RD, Hon, G, Tonti-Filippini, J, Nery, JR, Lee, L, Ye, Z, Ngo, QM, Edsall, L, Antosiewicz-Bourget, J, Stewart, R, Ruotti, V, Millar, AH, Thomson, JA, Ren, B, Ecker, JR

Nature 2009
16153702 Core transcriptional regulatory circuitry in human embryonic stem cells

Boyer, LA, Lee, TI, Cole, MF, Johnstone, SE, Levine, SS, Zucker, JP, Guenther, MG, Kumar, RM, Murray, HL, Jenner, RG, Gifford, DK, Melton, DA, Jaenisch, R, Young, RA

Cell 2005
21816365 BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages

Bernardo, AS, Faial, T, Gardner, L, Niakan, KK, Ortmann, D, Senner, CE, Callery, EM, Trotter, MW, Hemberger, M, Smith, JC, Bardwell, L, Moffett, A, Pedersen, RA

Cell Stem Cell 2011
17068183 Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells

Babaie, Y, Herwig, R, Greber, B, Brink, TC, Wruck, W, Groth, D, Lehrach, H, Burdon, T, Adjaye, J

Stem Cells 2007
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Authored
May, B  (2013-01-03)
Reviewed
Wang, J  (2014-01-23)
Created
D'Eustachio, P  (2013-01-06)
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