POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation

Stable Identifier
R-HSA-2892245
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm, cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
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POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
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POU5F1 (OCT4), SOX2, and NANOG bind elements in the promoters of target genes. The target genes of each transcription factor overlap extensively: POU5F1, SOX2, and NANOG co-occupy at least 353 genes (Boyer et al. 2005). About half of POU5F1 targets also bind SOX2 and about 90% of these also bind NANOG (Boyer et al. 2005). Upon binding the transcription factors activate expression of one subset of target genes in the core transcriptional network of pluripotent stem cells and repress another subset (Kim et al. 2006, Matoba et al. 2006, Player et al. 2006, Assou et al. 2007, Babaie et al. 2007, Chavez et al. 2009, Jung et al. 2010). The target genes listed in this module are the repressed genes. Caution must be used when making inferences about human stem cells from mouse stem cells because of significant differences between the two species (Ginis et al. 2004).
Literature References
PubMed ID Title Journal Year
16153702 Core transcriptional regulatory circuitry in human embryonic stem cells

Gifford, DK, Jaenisch, R, Lee, TI, Young, RA, Kumar, RM, Guenther, MG, Levine, SS, Boyer, LA, Jenner, RG, Cole, MF, Zucker, JP, Murray, HL, Johnstone, SE, Melton, DA

Cell 2005
17183653 Dissecting Oct3/4-regulated gene networks in embryonic stem cells by expression profiling

Sharov, AA, Carter, MG, Niwa, H, Masui, S, Matoba, R, Ko, MS, Ohtsuka, S

PLoS One 2006
16846370 Comparisons between transcriptional regulation and RNA expression in human embryonic stem cell lines

Player, A, Rao, M, Puri, RK, Wang, Y, Kawasaki, ES, Bhattacharya, B

Stem Cells Dev 2006
15110706 Differences between human and mouse embryonic stem cells

Itskovitz-Eldor, J, Miura, T, Amit, M, Thies, S, Rao, MS, Carpenter, MK, Hoke, A, Gerecht-Nir, S, Ginis, I, Luo, Y, Brandenberger, R

Dev Biol 2004
20505756 A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells

Adjaye, J, Kahlem, P, Lehrach, H, Vilo, J, Peterson, H, Chavez, L, Jung, M

PLoS One 2010
19604364 In silico identification of a core regulatory network of OCT4 in human embryonic stem cells using an integrated approach

Herwig, R, Adjaye, J, Bais, AS, Lehrach, H, Vingron, M, Chavez, L

BMC Genomics 2009
17068183 Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells

Babaie, Y, Groth, D, Wruck, W, Greber, B, Lehrach, H, Brink, TC, Burdon, T, Herwig, R, Adjaye, J

Stem Cells 2007
17204602 A meta-analysis of human embryonic stem cells transcriptome integrated into a web-based expression atlas

Le Carrour, T, Hamamah, S, De Vos, J, Ström, S, Hovatta, O, Assou, S, Klein, B, Marty, S, Réme, T, Hugnot, JP, Gabelle, A, Gasca, S, Nadal, L, Tondeur, S, Pantesco, V

Stem Cells 2007
16819296 Profiling of differentially expressed genes in human stem cells by cDNA microarray

Cho, YS, Kang, HC, Kim, HS, Kim, KS, Jeon, J, Do, BR, Heo, HS, Jung, DY, Kim, CG, Kim, CG, Cha, KJ, Lee, JJ, Shin, JH

Mol Cells 2006
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Cross References
BioModels Database
Authored
May, B  (2013-01-01)
Reviewed
Wang, J  (2014-01-23)
Created
May, B  (2013-01-02)
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