POU5F1 (OCT4), SOX2, NANOG bind the DKK1 promoter

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The DKK1 gene is bound by POU5F1 (OCT4) (Boyer et al. 2005, Jin et al. 2007, Jung et al. 2010), SOX2 (Lister et al. 2009), and NANOG (Boyer et al. 2005, Lister et al. 2009) in embryonic stem cells and POU5F1 (Babaie et al. 2007, Kunarso et al. 2010) represses expression. In mesenchymal stem cells, however, SOX2 appears to activate DKK1 expression (Park et al. 2012). DKK1 is a soluble inhibitor of Wnt signaling that binds the LRP5 receptor (reviewed in Pinzone et al. 2009). As inferred from mouse, DKK1 induces differentiation to neuroectoderm (Kong and Zhang 2009).

Literature References
PubMed ID Title Journal Year
19057969 Dickkopf (Dkk) 1 promotes the differentiation of mouse embryonic stem cells toward neuroectoderm

Kong, XB, Zhang, C

In Vitro Cell. Dev. Biol. Anim. 2009
19829295 Human DNA methylomes at base resolution show widespread epigenomic differences

Lister, R, Pelizzola, M, Dowen, RH, Hawkins, RD, Hon, G, Tonti-Filippini, J, Nery, JR, Lee, L, Ye, Z, Ngo, QM, Edsall, L, Antosiewicz-Bourget, J, Stewart, R, Ruotti, V, Millar, AH, Thomson, JA, Ren, B, Ecker, JR

Nature 2009
20526341 Transposable elements have rewired the core regulatory network of human embryonic stem cells

Kunarso, G, Chia, NY, Jeyakani, J, Hwang, C, Lu, X, Chan, YS, Ng, HH, Bourque, G

Nat. Genet. 2010
16153702 Core transcriptional regulatory circuitry in human embryonic stem cells

Boyer, LA, Lee, TI, Cole, MF, Johnstone, SE, Levine, SS, Zucker, JP, Guenther, MG, Kumar, RM, Murray, HL, Jenner, RG, Gifford, DK, Melton, DA, Jaenisch, R, Young, RA

Cell 2005
17567999 Identification of an OCT4 and SRY regulatory module using integrated computational and experimental genomics approaches

Jin, VX, O'Geen, H, Iyengar, S, Green, R, Farnham, PJ

Genome Res. 2007
18687985 The role of Dickkopf-1 in bone development, homeostasis, and disease

Pinzone, JJ, Hall, BM, Thudi, NK, Vonau, M, Qiang, YW, Rosol, TJ, Shaughnessy, JD

Blood 2009
20505756 A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells

Jung, M, Peterson, H, Chavez, L, Kahlem, P, Lehrach, H, Vilo, J, Adjaye, J

PLoS One 2010
17068183 Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells

Babaie, Y, Herwig, R, Greber, B, Brink, TC, Wruck, W, Groth, D, Lehrach, H, Burdon, T, Adjaye, J

Stem Cells 2007
22015605 SOX2 has a crucial role in the lineage determination and proliferation of mesenchymal stem cells through Dickkopf-1 and c-MYC

Park, SB, Seo, KW, So, AY, Seo, MS, Yu, KR, Kang, SK, Kang, KS

Cell Death Differ. 2012
Participant Of
Cite Us!