POU5F1 (OCT4), SOX2, NANOG bind the HHEX promoter

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

The HHEX gene is bound by POU5F1 (OCT4) (Boyer et al. 2005), SOX2 (Boyer et al. 2005), and NANOG (Boyer et al. 2005, Lister et al. 2009) and POU5F1 represses expression (Babaie et al. 2007, Kunarso et al. 2010). POU5F1, SOX2, and NANOG bind adjacently (Boyer et al. 2005) therefore POU5F1 and SOX2 may heterodimerize. As inferred from mouse, HHEX is required for hepatic differentiation (Hunter et al. 2007), hematopoiesis (Jayaraman et al. 2000), and endodermal tissues for forebrain and thyroid (Martinez Barbera et al. 2000).

Literature References
PubMed ID Title Journal Year
19829295 Human DNA methylomes at base resolution show widespread epigenomic differences

Lister, R, Pelizzola, M, Dowen, RH, Hawkins, RD, Hon, G, Tonti-Filippini, J, Nery, JR, Lee, L, Ye, Z, Ngo, QM, Edsall, L, Antosiewicz-Bourget, J, Stewart, R, Ruotti, V, Millar, AH, Thomson, JA, Ren, B, Ecker, JR

Nature 2009
11077116 The homeodomain protein PRH influences the differentiation of haematopoietic cells

Jayaraman, PS, Frampton, J, Goodwin, G

Leuk. Res. 2000
20526341 Transposable elements have rewired the core regulatory network of human embryonic stem cells

Kunarso, G, Chia, NY, Jeyakani, J, Hwang, C, Lu, X, Chan, YS, Ng, HH, Bourque, G

Nat. Genet. 2010
16153702 Core transcriptional regulatory circuitry in human embryonic stem cells

Boyer, LA, Lee, TI, Cole, MF, Johnstone, SE, Levine, SS, Zucker, JP, Guenther, MG, Kumar, RM, Murray, HL, Jenner, RG, Gifford, DK, Melton, DA, Jaenisch, R, Young, RA

Cell 2005
10804184 The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation

Martinez Barbera, JP, Clements, M, Thomas, P, Rodriguez, T, Meloy, D, Kioussis, D, Beddington, RS

Development 2000
17580084 The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis

Hunter, MP, Wilson, CM, Jiang, X, Cong, R, Vasavada, H, Kaestner, KH, Bogue, CW

Dev. Biol. 2007
17068183 Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells

Babaie, Y, Herwig, R, Greber, B, Brink, TC, Wruck, W, Groth, D, Lehrach, H, Burdon, T, Adjaye, J

Stem Cells 2007
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