POU5F1 (OCT4), NANOG bind the GATA6 promoter

Stable Identifier
R-HSA-2972952
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

POU5F1 (OCT4) (Boyer et al. 2005) and NANOG (Boyer et al. 2005, Lister et al. 2009) bind the promoter of the GATA6 gene and POU5F1 represses expression (Babaie et al. 2007, Greber et al. 2007, Kunarso et al. 2010). As inferred from mouse GATA6 is required for endoderm differentiatiation where it directly activates Bmp2 expression (Wang et al. 2011, Rong et al. 2012).

Literature References
PubMed ID Title Journal Year
20526341 Transposable elements have rewired the core regulatory network of human embryonic stem cells

Kunarso, G, Chia, NY, Jeyakani, J, Hwang, C, Lu, X, Chan, YS, Ng, HH, Bourque, G

Nat. Genet. 2010
19829295 Human DNA methylomes at base resolution show widespread epigenomic differences

Lister, R, Pelizzola, M, Dowen, RH, Hawkins, RD, Hon, G, Tonti-Filippini, J, Nery, JR, Lee, L, Ye, Z, Ngo, QM, Edsall, L, Antosiewicz-Bourget, J, Stewart, R, Ruotti, V, Millar, AH, Thomson, JA, Ren, B, Ecker, JR

Nature 2009
16153702 Core transcriptional regulatory circuitry in human embryonic stem cells

Boyer, LA, Lee, TI, Cole, MF, Johnstone, SE, Levine, SS, Zucker, JP, Guenther, MG, Kumar, RM, Murray, HL, Jenner, RG, Gifford, DK, Melton, DA, Jaenisch, R, Young, RA

Cell 2005
17506876 Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal

Greber, B, Lehrach, H, Adjaye, J

BMC Dev. Biol. 2007
22855527 GATA-6 promotes cell survival by up-regulating BMP-2 expression during embryonic stem cell differentiation

Rong, L, Liu, J, Qi, Y, Graham, AM, Parmacek, MS, Li, S

Mol. Biol. Cell 2012
17068183 Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells

Babaie, Y, Herwig, R, Greber, B, Brink, TC, Wruck, W, Groth, D, Lehrach, H, Burdon, T, Adjaye, J

Stem Cells 2007
20925113 Ectopic expression of GATA6 bypasses requirement for Grb2 in primitive endoderm formation

Wang, Y, Smedberg, JL, Cai, KQ, Capo-Chichi, DC, Xu, XX

Dev. Dyn. 2011
Participants
Participant Of
Authored
Reviewed
Created
Cite Us!