CLEC7A (Dectin-1) signals through the classic calcineurin/NFAT pathway through Syk activation phospholipase C-gamma 2 (PLCG2) leading to increased soluble IP3 (inositol trisphosphate). IP3 is able to bind endoplasmic Ca2+ channels, resulting in an influx of Ca2+ into the cytoplasm. This increase in calcium concentration induces calcineurin activation and consequently, dephosphorylation of NFAT and its translocation into the nucleus, triggering gene transcription and extracellular release of Interleukin-2 (Plato et al. 2013, Goodridge et al. 2007, Mourao-Sa et al. 2011).
Goodridge, HS, Simmons, RM, Underhill, DM
Fric, J, Zelante, T, Wong, AY, Mertes, A, Yu, HB, Ricciardi-Castagnoli, P
Mourão-Sá, D, Robinson, MJ, Zelenay, S, Sancho, D, Chakravarty, P, Larsen, R, Plantinga, M, Van Rooijen, N, Soares, MP, Lambrecht, B, Reis e Sousa, C
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