Reactome | CLEC7A (Dectin-1) induces NFAT activation

CLEC7A (Dectin-1) induces NFAT activation

Stable Identifier

R-HSA-5607763

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane, cytosol

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CLEC7A (Dectin-1) induces NFAT activation

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CLEC7A (Dectin-1) signals through the classic calcineurin/NFAT pathway through Syk activation phospholipase C-gamma 2 (PLCG2) leading to increased soluble IP3 (inositol trisphosphate). IP3 is able to bind endoplasmic Ca2+ channels, resulting in an influx of Ca2+ into the cytoplasm. This increase in calcium concentration induces calcineurin activation and consequently, dephosphorylation of NFAT and its translocation into the nucleus, triggering gene transcription and extracellular release of Interleukin-2 (Plato et al. 2013, Goodridge et al. 2007, Mourao-Sa et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
17312158	Dectin-1 stimulation by Candida albicans yeast or zymosan triggers NFAT activation in macrophages and dendritic cells Goodridge, HS, Simmons, RM, Underhill, DM	J. Immunol.	2007
22611159	NFAT control of innate immunity Fric, J, Zelante, T, Wong, AY, Mertes, A, Yu, HB, Ricciardi-Castagnoli, P	Blood	2012
21728173	CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses Mourão-Sá, D, Robinson, MJ, Zelenay, S, Sancho, D, Chakravarty, P, Larsen, R, Plantinga, M, Van Rooijen, N, Soares, MP, Lambrecht, B, Reis e Sousa, C	Eur. J. Immunol.	2011