CLEC7A (Dectin-1) induces NFAT activation

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R-HSA-5607763
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Homo sapiens
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CLEC7A (Dectin-1) signals through the classic calcineurin/NFAT pathway through Syk activation phospholipase C-gamma 2 (PLCG2) leading to increased soluble IP3 (inositol trisphosphate). IP3 is able to bind endoplasmic Ca2+ channels, resulting in an influx of Ca2+ into the cytoplasm. This increase in calcium concentration induces calcineurin activation and consequently, dephosphorylation of NFAT and its translocation into the nucleus, triggering gene transcription and extracellular release of Interleukin-2 (Plato et al. 2013, Goodridge et al. 2007, Mourao-Sa et al. 2011).

Literature References
PubMed ID Title Journal Year
22611159 NFAT control of innate immunity

Ricciardi-Castagnoli, P, Zelante, T, Mertes, A, Wong, AY, Yu, HB, Fric, J

Blood 2012
17312158 Dectin-1 stimulation by Candida albicans yeast or zymosan triggers NFAT activation in macrophages and dendritic cells

Simmons, RM, Underhill, DM, Goodridge, HS

J. Immunol. 2007
21728173 CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses

Sancho, D, Chakravarty, P, Zelenay, S, Mourão-Sá, D, Reis e Sousa, C, Lambrecht, B, Soares, MP, Van Rooijen, N, Robinson, MJ, Plantinga, M, Larsen, R

Eur. J. Immunol. 2011
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