Activation of RAC1 by VAV

Stable Identifier
R-HSA-2730840
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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Rac1 exists in inactive state in the cytosol until the reception of extracellular signals by the cell. To be functional Rac1 is rapidly targeted to the plasma membrane upon cell stimulation. The main factors involved in this mobilisation are the Rac GEFs like VAV and phospholipids (PtdIns(4,5)P2, PtdIns(3,4,5) P3) and lipid rafts at the plasma membrane. VAV catalyses the disassociation of GDP from Rac1 by modifying the nucleotide-binding site such that GDP is released and subsequently replaced. The incoming GTP occupies the nucleotide binding site and finally displaces VAV from Rac1 (Bos et al. 2007, Bustelo et al. 2012).

Literature References
PubMed ID Title Journal Year
17540168 GEFs and GAPs: critical elements in the control of small G proteins

Wittinghofer, A, Rehmann, H, Bos, JL

Cell 2007
12670394 Vav1: a key signal transducer downstream of the TCR

Ardouin, L, Tybulewicz, VL, Reynolds, LF, Prisco, A

Immunol Rev 2003
Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane]

Orthologous Events
Authored
Reviewed
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