PTK6-mediated phosphorylation activates STAT3 transcription factor via STAP2 adapter protein. STAT3 transcriptional target SOCS3 is a negative regulator of PTK6 and inhibits PTK6-mediated phosphorylation of STAT3, thus creating a negative feedback loop (Liu et al. 2006, Ikeda et al. 2009, Ikeda et al. 2010). PTK6 may also activate STAT5-mediated transcription (Ikeda et al. 2011).
Liu, L, Gao, Y, Qiu, H, Miller, WT, Poli, V, Reich, NC
Ikeda, O, Miyasaka, Y, Sekine, Y, Mizushima, A, Muromoto, R, Nanbo, A, Yoshimura, A, Matsuda, T
Ikeda, O, Mizushima, A, Sekine, Y, Yamamoto, C, Muromoto, R, Nanbo, A, Oritani, K, Yoshimura, A, Matsuda, T
Ikeda, O, Sekine, Y, Mizushima, A, Nakasuji, M, Miyasaka, Y, Yamamoto, C, Muromoto, R, Nanbo, A, Oritani, K, Yoshimura, A, Matsuda, T
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