Reactome | PTK6 Activates STAT3

PTK6 Activates STAT3

Stable Identifier

R-HSA-8849474

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this pathway in the Pathway Browser

PTK6-mediated phosphorylation activates STAT3 transcription factor via STAP2 adapter protein. STAT3 transcriptional target SOCS3 is a negative regulator of PTK6 and inhibits PTK6-mediated phosphorylation of STAT3, thus creating a negative feedback loop (Liu et al. 2006, Ikeda et al. 2009, Ikeda et al. 2010). PTK6 may also activate STAT5-mediated transcription (Ikeda et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
19393627	STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation Ikeda, O, Miyasaka, Y, Sekine, Y, Mizushima, A, Muromoto, R, Nanbo, A, Yoshimura, A, Matsuda, T	Biochem. Biophys. Res. Commun.	2009
16568091	Identification of STAT3 as a specific substrate of breast tumor kinase Liu, L, Gao, Y, Qiu, H, Miller, WT, Poli, V, Reich, NC	Oncogene	2006
21205088	Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells Ikeda, O, Mizushima, A, Sekine, Y, Yamamoto, C, Muromoto, R, Nanbo, A, Oritani, K, Yoshimura, A, Matsuda, T	Cancer Sci.	2011
20929863	Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells Ikeda, O, Sekine, Y, Mizushima, A, Nakasuji, M, Miyasaka, Y, Yamamoto, C, Muromoto, R, Nanbo, A, Oritani, K, Yoshimura, A, Matsuda, T	J. Biol. Chem.	2010