Reactome | TPCN1/2 transport lysosomal Ca2+ to cytosol

TPCN1/2 transport lysosomal Ca2+ to cytosol

Stable Identifier

R-HSA-2685505

Type

Reaction [transition]

Species

Homo sapiens

Compartment

lysosomal lumen, lysosomal membrane, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

TPCN1/2 transport lysosomal Ca2+ to cytosol

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Calcium (Ca2+) can be mobilised from intracellular stores by the presence of nicotinic acid adenine dinucleotide phosphate (NAADP). Two pore calcium channel proteins 1 and 2 (TPCN1 and 2) are expressed on endosomal (not shown here) and lysosomal membranes and mediate the mobilization of Ca2+ from these organelles when activated by NAADP (Brailoiu et al. 2009, Calcraft et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19387438	NAADP mobilizes calcium from acidic organelles through two-pore channels Calcraft, PJ, Ruas, M, Pan, Z, Cheng, X, Arredouani, A, Hao, X, Tang, J, Rietdorf, K, Teboul, L, Chuang, KT, Lin, P, Xiao, R, Wang, C, Zhu, Y, Lin, Y, Wyatt, CN, Parrington, J, Ma, J, Evans, AM, Galione, A, Zhu, MX	Nature	2009
19620632	Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling Brailoiu, E, Churamani, D, Cai, X, Schrlau, MG, Brailoiu, GC, Gao, X, Hooper, R, Boulware, MJ, Dun, NJ, Marchant, JS, Patel, S	J. Cell Biol.	2009