JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin

Stable Identifier
R-HSA-2671742
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin
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Phosphorylated JAK2 in the LEP:LEPR:JAK2:SHP2 complex phosphorylates SHP2 (Carpenter et al. 1998). Phosphorylated SHP2, in turn, activates the RAS-MAPK signaling pathway, possibly via GRB2:SOS.

Literature References
PubMed ID Title Journal Year
9600917 Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor

Symes, A, Stahl, N, Farruggella, TJ, Yancopoulos, GD, Carpenter, LR, Karow, ML

Proc. Natl. Acad. Sci. U.S.A. 1998
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of LEP:p-LEPR:p-JAK2:SHP2 [plasma membrane]

Physical Entity
LEP:p-LEPR:p-JAK2:SHP2 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Jak2 Phosphorylates Shp2 in Response to Leptin (Mus musculus)
Authored
May, B  (2012-11-15)
Reviewed
Scherer, T  (2013-08-31)
Gonzalez-Perez, RR  (2013-10-26)
Created
May, B  (2012-11-24)
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