Jak2 Phosphorylates Shp2 in Response to Leptin

Stable Identifier
R-MMU-2671740
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Jak2 Phosphorylates Shp2 in Response to Leptin

Jak2 phosphorylates Shp2 within the Lep:Lepr:Jak2:Shp2 complex. Phosphorylated Shp2 activates the MAPK signaling pathway.

Literature References
PubMed ID Title Journal Year
11085989 Divergent roles of SHP-2 in ERK activation by leptin receptors

Bjørbaek, C, Buchholz, RM, Davis, SM, Bates, SH, Pierroz, DD, Gu, H, Neel, BG, Myers, MG, Flier, JS

J. Biol. Chem. 2001
10449753 Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction

Li, C, Friedman, JM

Proc. Natl. Acad. Sci. U.S.A. 1999
10799542 Activation of downstream signals by the long form of the leptin receptor

Banks, AS, Davis, SM, Bates, SH, Myers, MG

J. Biol. Chem. 2000
Participants
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Lep:p-Lepr:p-Jak2:Shp2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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