Endocytosis and degradation of apoA-I

Stable Identifier
R-HSA-264834
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
endosome
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Endocytosis and degradation of apoA-I
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ApoA-I bound to CUBN:AMN on the cell surface is endocytosed, moved to lysosomes, and degraded (Kozyraki et al. 1999). It is not known whether the CUBN:AMN complex is also degraded or recycled to the cell surface.

Literature References
PubMed ID Title Journal Year
10371504 The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein

Fyfe, JC, Krahe, R, Kozyraki, R, Kristiansen, M, Moestrup, SK, Aminoff, M, de la Chapelle, A, Jacobsen, C, Verroust, PJ, Cui, S, Christensen, EI, Gerdes, C

Nat Med 1999
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Orthologous Events
Endocytosis and degradation of apoA-I (Bos taurus)
Endocytosis and degradation of apoA-I (Rattus norvegicus)
Authored
D'Eustachio, P  (2008-05-12)
Reviewed
Jassal, B  (2008-06-13)
Created
D'Eustachio, P  (2008-04-10)
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