Endocytosis and degradation of apoA-I

Stable Identifier
R-HSA-264834
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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ApoA-I bound to CUBN:AMN on the cell surface is endocytosed, moved to lysosomes, and degraded (Kozyraki et al. 1999). It is not known whether the CUBN:AMN complex is also degraded or recycled to the cell surface.

Literature References
PubMed ID Title Journal Year
10371504 The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein

Kozyraki, R, Fyfe, JC, Kristiansen, M, Gerdes, C, Jacobsen, C, Cui, S, Christensen, EI, Aminoff, M, de la Chapelle, A, Krahe, R, Verroust, PJ, Moestrup, SK

Nat Med 1999
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