Reactome | Endocytosis and degradation of apoA-I

Endocytosis and degradation of apoA-I

Stable Identifier

R-HSA-264834

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

endosome

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ApoA-I bound to CUBN:AMN on the cell surface is endocytosed, moved to lysosomes, and degraded (Kozyraki et al. 1999). It is not known whether the CUBN:AMN complex is also degraded or recycled to the cell surface.

Literature References

PubMed ID	Title	Journal	Year
10371504	The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein Kozyraki, R, Fyfe, JC, Kristiansen, M, Gerdes, C, Jacobsen, C, Cui, S, Christensen, EI, Aminoff, M, de la Chapelle, A, Krahe, R, Verroust, PJ, Moestrup, SK	Nat Med	1999