Reactome | Loading of acetylcholine in synaptic vesicles

Loading of acetylcholine in synaptic vesicles

Stable Identifier

R-HSA-264615

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, clathrin-sculpted acetylcholine transport vesicle lumen

ReviewStatus

5/5

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Loading of acetylcholine in synaptic vesicles

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Acetylcholine is actively transported from the cytosol to the lumen of the synaptic vesicle by vesicular acetylcholine transporter. Two protons are exchanged for 1 molecule of acetylcholine. The vesicular acetylcholine transporter is located in the membrane of the synaptic vesicle.

Literature References

PubMed ID	Title	Journal	Year
8071310	Functional identification of a vesicular acetylcholine transporter and its expression from a "cholinergic" gene locus Erickson, JD, Varoqui, H, Schäfer, MK, Modi, W, Diebler, MF, Weihe, E, Rand, J, Eiden, LE, Bonner, TI, Usdin, TB	J Biol Chem	1994