Jak2 Autophosphorylates in Response to Leptin

Stable Identifier
R-MMU-2586548
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
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Jak2 Autophosphorylates in Response to Leptin

Upon binding leptin the leptin receptor (Lepr) changes conformation and activates Jak2 kinase. Jak2 then phosphorylates itself, which greatly enhances its kinase activity.

Literature References
PubMed ID Title Journal Year
20304997 Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity

Argetsinger, LS, Stuckey, JA, Robertson, SA, Koleva, RI, Cline, JM, Marto, JA, Myers MG, Jr, Carter-Su, C

Mol Endocrinol 2010
9405487 Divergent signaling capacities of the long and short isoforms of the leptin receptor

Bjørbaek, C, Uotani, S, da Silva, B, Flier, JS

J. Biol. Chem. 1997
Participants
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Lep:Lepr:Jak2 [plasma membrane]
Physical Entity
Activity
This event is regulated
Orthologous Events
Authored
Reviewed
Created