p-Y986,Y1079,Y1141-LEPR dimer

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
9020115 Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization

White, DW, Kuropatwinski, KK, Devos, R, Baumann, H, Tartaglia, LA

J. Biol. Chem. 1997
9218470 Ligand-independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding

Devos, R, Guisez, Y, Van der Heyden, J, White, DW, Kalai, M, Fountoulakis, M, Plaetinck, G

J. Biol. Chem. 1997
15051545 BiaCore analysis of leptin-leptin receptor interaction: evidence for 1:1 stoichiometry

Mistrík, P, Moreau, F, Allen, JM

Anal. Biochem. 2004
10227390 Evidence for ligand-independent homo-oligomerization of leptin receptor (OB-R) isoforms: a proposed mechanism permitting productive long-form signaling in the presence of excess short-form expression

White, DW, Tartaglia, LA

J. Cell. Biochem. 1999
9600917 Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor

Carpenter, LR, Farruggella, TJ, Symes, A, Karow, ML, Yancopoulos, GD, Stahl, N

Proc. Natl. Acad. Sci. U.S.A. 1998
12734179 Activation of the leptin receptor by a ligand-induced conformational change of constitutive receptor dimers

Couturier, C, Jockers, R

J. Biol. Chem. 2003
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