Reactome | METAP1/2 demethylates GNAT1

METAP1/2 demethylates GNAT1

Stable Identifier

R-HSA-2534096

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

All eukaryotic proteins synthesized in the cytosol are initiated by methionine (Met). For the maturation of many proteins, the removal of N-terminal Met is essential and is mediated by methionine-aminopeptidases (METAPs). In human, there are two forms, METAP1 and 2 (Arfin et al. 1995). These enzymes utilise 2 cobalt ions (Co2+) as cofactors (Addlagatta et al. 2005, Hu et al. 2006, Marino et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
16274222	Structural basis for the functional differences between type I and type II human methionine aminopeptidases Addlagatta, A, Hu, X, Liu, JO, Matthews, BW	Biochemistry	2005
7644482	Eukaryotic methionyl aminopeptidases: two classes of cobalt-dependent enzymes Arfin, SM, Kendall, RL, Hall, L, Weaver, LH, Stewart, AE, Matthews, BW, Bradshaw, RA	Proc. Natl. Acad. Sci. U.S.A.	1995
17636946	Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore Marino, JP, Fisher, PW, Hofmann, GA, Kirkpatrick, RB, Janson, CA, Johnson, RK, Ma, C, Mattern, M, Meek, TD, Ryan, MD, Schulz, C, Smith, WW, Tew, DG, Tomazek, TA, Veber, DF, Xiong, WC, Yamamoto, Y, Yamashita, K, Yang, G, Thompson, SK	J. Med. Chem.	2007
17114291	Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression Hu, X, Addlagatta, A, Lu, J, Matthews, BW, Liu, JO	Proc. Natl. Acad. Sci. U.S.A.	2006