atRAL is reduced to atROL

Stable Identifier
R-HSA-2465940
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, photoreceptor outer segment membrane
ReviewStatus
5/5
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atRAL is reduced to atROL
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All-trans-retinal (atRAL) can diffuse across membranes to the cytosol and is reduced to all-trans-retinol (atROL) by the action of a short-chain dehydrogenase/reductase 3 using NADP+/NADPH as cofactor (Haeseleer et al. 1998).
Literature References
PubMed ID Title Journal Year
9705317 Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal

Haeseleer, F, Huang, J, Lebioda, L, Saari, JC, Palczewski, K

J. Biol. Chem. 1998
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Output
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as an event of
Catalyst Activity

all-trans-retinol dehydrogenase (NADP+) activity of DHRS3 [photoreceptor outer segment membrane]

Physical Entity
DHRS3 [photoreceptor outer segment membrane] (Homo sapiens)
Activity
all-trans-retinol dehydrogenase (NADP+) activity (GO:0052650)
Orthologous Events
atRAL is reduced to atROL (Bos taurus)
atRAL is reduced to atROL (Caenorhabditis elegans)
atRAL is reduced to atROL (Canis familiaris)
atRAL is reduced to atROL (Danio rerio)
atRAL is reduced to atROL (Drosophila melanogaster)
atRAL is reduced to atROL (Gallus gallus)
atRAL is reduced to atROL (Mus musculus)
atRAL is reduced to atROL (Rattus norvegicus)
atRAL is reduced to atROL (Saccharomyces cerevisiae)
atRAL is reduced to atROL (Sus scrofa)
atRAL is reduced to atROL (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2012-09-04)
Reviewed
Blaner, WS  (2013-01-31)
Created
Jassal, B  (2012-09-04)
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