11cRDH oxidises 11cROL to 11cRAL

Stable Identifier
R-HSA-2465921
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
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11cRDH oxidises 11cROL to 11cRAL
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11-cis-specific retinol dehydrogenase (11cRDH) activity found in chicken retina mediates the oxidation of 11-cis-retinol (11cROL) to 11-cis-retinal (11cRAL) using NADP+ as cofactor (Mata et al. 2002). The chicken protein that possesses this activity has not yet been identified. The actual enzyme responsible remains to be identified in human, even as evidence exists for this activity and for the alternative retinoid (visual) cycle in cones (Wang & Kefalov 2009). 11cRAL is the visual chromophore that is able to bind to opsins.
Literature References
PubMed ID Title Journal Year
19781940 An alternative pathway mediates the mouse and human cone visual cycle

Kefalov, VJ, Wang, JS

Curr. Biol. 2009
12367507 Isomerization and oxidation of vitamin a in cone-dominant retinas: a novel pathway for visual-pigment regeneration in daylight.

Travis, GH, Radu, RA, Clemmons, RC, Mata, NL

Neuron 2002
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Output
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as an event of
Catalyst Activity

all-trans-retinol dehydrogenase (NADP+) activity of 11cRDH [endoplasmic reticulum membrane]

Physical Entity
11cRDH [endoplasmic reticulum membrane] (Homo sapiens)
Activity
all-trans-retinol dehydrogenase (NADP+) activity (GO:0052650)
Cross References
Rhea
Authored
Jassal, B  (2012-09-04)
Reviewed
Blaner, WS  (2013-01-31)
Created
Jassal, B  (2012-09-04)
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