Reactome | IRS-related events triggered by IGF1R

IRS-related events triggered by IGF1R

Stable Identifier

R-HSA-2428928

Type

Pathway

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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The phosphorylated type 1 insulin-like growth factor receptor phosphorylates IRS1, IRS2, IRS4 and possibly other IRS/DOK family members (reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et al. 2010, Parrella et al. 2010, Siddle et al. 2012). The phosphorylated IRS proteins serve as scaffolds that bind the effector molecules PI3K and GRB2:SOS. PI3K then activates PKB (AKT) signaling while GRB2:SOS activates RAS-RAF-MAPK signaling.

Literature References

PubMed ID	Title	Journal	Year
22649417	Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances Siddle, K	Front Endocrinol (Lausanne)	2012
20098959	Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain Longo, VD, Parrella, E	ScientificWorldJournal	2010
20975071	Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer Maki, RG	J. Clin. Oncol.	2010
17598937	Biological & physiological aspects of action of insulin-like growth factor peptide family Knezević, J, Matijević, T, Pavelić, J	Indian J. Med. Res.	2007
21042815	The IGF system Ghigo, E, Annunziata, M, Granata, R	Acta Diabetol	2011
18927274	The type 1 insulin-like growth factor receptor pathway Chitnis, MM, Macaulay, VM, Protheroe, AS, Pollak, M, Yuen, JS	Clin. Cancer Res.	2008