Reactome | IGF1,2:IGF1R autophosphorylates

IGF1,2:IGF1R autophosphorylates

Stable Identifier

R-HSA-2404199

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

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The beta peptide of the type 1 insulin-like growth factor (IGF1R) spans the plasma membrane and trans-autophosphorylates tyrosine residues in response to binding of either IGF1 or IGF2 by the extracellular alpha peptide (LeBon et al. 1986, Yu et al. 1986, Doronio et al. 1990, Hernandez-Sanchez et al. 1995, Alvino et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
3015966	Similar control mechanisms regulate the insulin and type I insulin-like growth factor receptor kinases. Affinity-purified insulin-like growth factor I receptor kinase is activated by tyrosine phosphorylation of its beta subunit Yu, KT, Peters, MA, Czech, MP	J. Biol. Chem.	1986
22140443	Understanding the mechanism of insulin and insulin-like growth factor (IGF) receptor activation by IGF-II Alvino, CL, Ong, SC, McNeil, KA, Delaine, C, Booker, GW, Wallace, JC, Forbes, BE	PLoS ONE	2011
3011795	Purification of insulin-like growth factor I receptor from human placental membranes LeBon, TR, Jacobs, S, Cuatrecasas, P, Kathuria, S, Fujita-Yamaguchi, Y	J. Biol. Chem.	1986
7493944	The role of the tyrosine kinase domain of the insulin-like growth factor-I receptor in intracellular signaling, cellular proliferation, and tumorigenesis Hernández-Sánchez, C, Blakesley, V, Kalebic, T, Helman, L, LeRoith, D	J. Biol. Chem.	1995
1697749	Insulin receptor is phosphorylated in response to treatment of HepG2 cells with insulin-like growth factor I Duronio, V	Biochem. J.	1990