Reactome | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)

Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)

Stable Identifier

R-HSA-2404192

DOI

10.3180/REACT_150359.1

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)

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Binding of IGF1 (IGF-I) or IGF2 (IGF-II) to the extracellular alpha peptides of the type 1 insulin-like growth factor receptor (IGF1R) triggers the activation of two major signaling pathways: the SOS-RAS-RAF-MAPK (ERK) pathway and the PI3K-PKB (AKT) pathway (recently reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et al. 2010, Parella et al. 2010, Annunziata et al. 2011, Siddle et al. 2012, Holzenberger 2012).

Literature References

PubMed ID	Title	Journal	Year
22649417	Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances Siddle, K	Front Endocrinol (Lausanne)	2012
20098959	Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain Longo, VD, Parrella, E	ScientificWorldJournal	2010
20975071	Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer Maki, RG	J. Clin. Oncol.	2010
22044904	Igf-I signaling and effects on longevity Holzenberger, M	Nestle Nutr Workshop Ser Pediatr Program	2011
17598937	Biological & physiological aspects of action of insulin-like growth factor peptide family Knezević, J, Matijević, T, Pavelić, J	Indian J. Med. Res.	2007
21042815	The IGF system Ghigo, E, Annunziata, M, Granata, R	Acta Diabetol	2011
18927274	The type 1 insulin-like growth factor receptor pathway Chitnis, MM, Macaulay, VM, Protheroe, AS, Pollak, M, Yuen, JS	Clin. Cancer Res.	2008