Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP

Stable Identifier
R-HSA-2393939
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
ADP-ribose + H2O => AMP + D-ribose 5-phosphate (cytosolic)
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Cytosolic NUDT5 dimer (ADP-ribose pyrophosphatase) catalyzes the hydrolysis of ADP-ribose to form AMP and D-ribose 5-phosphate. Each NUDT5 subunit is associated with three magnesium ions (Zha et al. 2006, 2008). NUDT5 also catalyzes the hydrolysis of 8-oxo-dGTP but with a strongly alkaline pH optimum (Ito et al. 2011) so the physiological relevance of this reaction is unclear and it is not annotated here.

Literature References
PubMed ID Title Journal Year
21389046 Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein

Hayakawa, H, Nakatsu, Y, Ito, R, Sekiguchi, M, Yamagata, Y, Setoyama, D

J. Biochem. 2011
18462755 Molecular mechanism of ADP-ribose hydrolysis by human NUDT5 from structural and kinetic studies

Ding, J, Ou, Y, Yu, B, Zhang, Y, Guo, Q, Zha, M, Zhong, C

J. Mol. Biol. 2008
17052728 Crystal structures of human NUDT5 reveal insights into the structural basis of the substrate specificity

Ding, J, Peng, Y, Hu, H, Zha, M, Zhong, C

J. Mol. Biol. 2006
Participants
Participates
Catalyst Activity

ADP-ribose diphosphatase activity of NUDT5 dimer [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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