Cytosolic NUDT5 dimer (ADP-ribose pyrophosphatase) catalyzes the hydrolysis of ADP-ribose to form AMP and D-ribose 5-phosphate. Each NUDT5 subunit is associated with three magnesium ions (Zha et al. 2006, 2008). NUDT5 also catalyzes the hydrolysis of 8-oxo-dGTP but with a strongly alkaline pH optimum (Ito et al. 2011) so the physiological relevance of this reaction is unclear and it is not annotated here.
Hayakawa, H, Nakatsu, Y, Ito, R, Sekiguchi, M, Yamagata, Y, Setoyama, D
Ding, J, Ou, Y, Yu, B, Zhang, Y, Guo, Q, Zha, M, Zhong, C
Ding, J, Peng, Y, Hu, H, Zha, M, Zhong, C
ADP-ribose diphosphatase activity of NUDT5 dimer [cytosol]
© 2022 Reactome
