Reactome | Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP

Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP

Stable Identifier

R-HSA-2393939

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ADP-ribose + H2O => AMP + D-ribose 5-phosphate (cytosolic)

ReviewStatus

5/5

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Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP

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Cytosolic NUDT5 dimer (ADP-ribose pyrophosphatase) catalyzes the hydrolysis of ADP-ribose to form AMP and D-ribose 5-phosphate. Each NUDT5 subunit is associated with three magnesium ions (Zha et al. 2006, 2008). NUDT5 also catalyzes the hydrolysis of 8-oxo-dGTP but with a strongly alkaline pH optimum (Ito et al. 2011) so the physiological relevance of this reaction is unclear and it is not annotated here.

Literature References

PubMed ID	Title	Journal	Year
21389046	Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein Ito, R, Sekiguchi, M, Setoyama, D, Nakatsu, Y, Yamagata, Y, Hayakawa, H	J. Biochem.	2011
18462755	Molecular mechanism of ADP-ribose hydrolysis by human NUDT5 from structural and kinetic studies Zha, M, Guo, Q, Zhang, Y, Yu, B, Ou, Y, Zhong, C, Ding, J	J. Mol. Biol.	2008
17052728	Crystal structures of human NUDT5 reveal insights into the structural basis of the substrate specificity Zha, M, Zhong, C, Peng, Y, Hu, H, Ding, J	J. Mol. Biol.	2006