Reactome | Emilin is found in elastic fibres

Emilin is found in elastic fibres

Stable Identifier

R-HSA-2328048

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Elastin microfibril interface located protein (EMILIN)-1 is localized to the microfibril-elastin interface (Bressan et al. 1993). It can bind elastin and fibulin-5 (Zanetti et al. 2004). Emilin1 knockout mice have ultrastructural alterations of the elastic fibers in aorta and skin, abnormal cell morphology and anchorage of endothelial and smooth muscle cells to elastic lamellae, and abnormal elastic fibers in cultured embryonic fibroblasts.

Literature References

PubMed ID	Title	Journal	Year
14701737	EMILIN-1 deficiency induces elastogenesis and vascular cell defects Zanetti, M, Braghetta, P, Sabatelli, P, Mura, I, Doliana, R, Colombatti, A, Volpin, D, Bonaldo, P, Bressan, GM	Mol. Cell. Biol.	2004