ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4

Stable Identifier
R-HSA-2267372
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4
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Inositol-tetrakisphosphate 1-kinase (ITPK1) phosphorylates Ins(1,3,4)P3 on O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway.
Literature References
PubMed ID Title Journal Year
11042108 Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase

Yang, X, Shears, SB

Biochem J 2000
Participants
Input
Output
Participates
as an event of
Catalyst Activity

inositol-1,3,4-trisphosphate 6-kinase activity of ITPK1 [cytosol]

Physical Entity
ITPK1 [cytosol] (Homo sapiens)
Activity
inositol-1,3,4-trisphosphate 6-kinase activity (GO:0052725)
Orthologous Events
ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Bos taurus)
ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Canis familiaris)
ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Danio rerio)
ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Dictyostelium discoideum)
ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Gallus gallus)
ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Mus musculus)
ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Rattus norvegicus)
ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Sus scrofa)
ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Xenopus tropicalis)
Cross References
Rhea
Authored
Akkerman, JW  (2010-10-29)
Reviewed
Ouwehand, WH  (2010-11-12)
Created
Jupe, S  (2012-05-25)
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