ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4

Stable Identifier
R-HSA-2267372
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Inositol-tetrakisphosphate 1-kinase (ITPK1) phosphorylates Ins(1,3,4)P3 on O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway.

Literature References
PubMed ID Title Journal Year
11042108 Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase

Yang, X, Shears, SB

Biochem J 2000
Participants
Input
Output
Participates
as an event of
Catalyst Activity

inositol-1,3,4-trisphosphate 6-kinase activity of ITPK1 [cytosol]

Physical Entity
ITPK1 [cytosol] (Homo sapiens)
Activity
inositol-1,3,4-trisphosphate 6-kinase activity (GO:0052725)
Orthologous Events
ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Bos taurus)
ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Canis familiaris)
ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Danio rerio)
ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Dictyostelium discoideum)
ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Gallus gallus)
ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Mus musculus)
ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Rattus norvegicus)
ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Sus scrofa)
ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Xenopus tropicalis)
Cross References
Rhea
Authored
Akkerman, JW  (2010-10-29)
Reviewed
Ouwehand, WH  (2010-11-12)
Created
Jupe, S  (2012-05-25)
Cite Us!