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ITPK1 [cytosol]
Stable Identifier
R-HSA-994132
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Inositol-tetrakisphosphate 1-kinase, ITPK1_HUMAN, Inositol 1,3,4-trisphosphate 5/6-kinase
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4 (Homo sapiens)
ITPK1 [cytosol] (Homo sapiens)
ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4 (Homo sapiens)
ITPK1 [cytosol] (Homo sapiens)
ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5 (Homo sapiens)
ITPK1 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Inositol phosphate metabolism (Homo sapiens)
Synthesis of IP3 and IP4 in the cytosol (Homo sapiens)
I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Homo sapiens)
ITPK1:Mg2+ [cytosol] (Homo sapiens)
ITPK1 [cytosol] (Homo sapiens)
I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Homo sapiens)
ITPK1:Mg2+ [cytosol] (Homo sapiens)
ITPK1 [cytosol] (Homo sapiens)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Homo sapiens)
INPP5(3)/ITPK1 [cytosol] (Homo sapiens)
ITPK1:Mg2+ [cytosol] (Homo sapiens)
ITPK1 [cytosol] (Homo sapiens)
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol (Homo sapiens)
ITPK1:Mg2+ [cytosol] (Homo sapiens)
ITPK1 [cytosol] (Homo sapiens)
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol (Homo sapiens)
ITPK1:Mg2+ [cytosol] (Homo sapiens)
ITPK1 [cytosol] (Homo sapiens)
I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Homo sapiens)
ITPK1:Mg2+ [cytosol] (Homo sapiens)
ITPK1 [cytosol] (Homo sapiens)
Synthesis of pyrophosphates in the cytosol (Homo sapiens)
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol (Homo sapiens)
ITPK1:Mg2+ [cytosol] (Homo sapiens)
ITPK1 [cytosol] (Homo sapiens)
I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol (Homo sapiens)
ITPK1:Mg2+ [cytosol] (Homo sapiens)
ITPK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13572 ITPK1
Gene Names
ITPK1
Chain
chain:1-414
Reference Genes
BioGPS Gene:3705 ITPK1
COSMIC (genes):ITPK1 ITPK1
CTD Gene:3705 ITPK1
dbSNP Gene:3705 ITPK1
ENSEMBL:ENSG00000100605 ITPK1
ENSEMBL_homo_sapiens_GENE:ENSG00000100605.17 ITPK1
ENSEMBL_homo_sapiens_GENE:ENSG00000274958.4 ITPK1
HGNC:6177 ITPK1
KEGG Gene (Homo sapiens):3705 ITPK1
Monarch:3705 ITPK1
NCBI Gene:3705 ITPK1
OMIM:601838 ITPK1
UCSC:Q13572 ITPK1
Reference Transcript
RefSeq:NM_001142593.2 ITPK1
RefSeq:NM_014216.5 ITPK1
RefSeq:NM_001142594.2 ITPK1
Other Identifiers
11718046_a_at
11718047_a_at
11743097_a_at
11751261_a_at
16796094
210197_PM_at
210197_at
210740_PM_s_at
210740_s_at
35755_at
3577161
3577162
3577163
3577164
3577165
3577166
3577167
3577168
3577169
3577171
3577175
3577176
3577179
3577182
3577184
3577195
3577209
3577220
3577239
3577240
3577241
3577242
3705
7980970
A_23_P37399
A_24_P109633
A_24_P167683
GE59220
GO:0000166
GO:0000287
GO:0000825
GO:0003824
GO:0005524
GO:0005829
GO:0005886
GO:0007165
GO:0007596
GO:0012501
GO:0016301
GO:0016310
GO:0016324
GO:0016740
GO:0016787
GO:0016853
GO:0021915
GO:0023052
GO:0032957
GO:0042060
GO:0046872
GO:0047325
GO:0048856
GO:0052725
GO:0052726
GO:0052835
GO:0070266
HMNXSV003035065
HMNXSV003049732
ILMN_1715674
PH_hs_0024748
TC14001453.hg
U51336_at
g12006345_3p_a_at
g13177675_3p_at
Participates
as a component of
ITPK1:Mg2+ [cytosol] (Homo sapiens)
Inferred To
Itpk1 [cytosol]
(Rattus norvegicus)
ITPK1 [cytosol]
(Bos taurus)
ITPK1 [cytosol]
(Canis familiaris)
ITPK1 [cytosol]
(Dictyostelium discoideum)
ITPK1 [cytosol]
(Gallus gallus)
ITPK1 [cytosol]
(Mus musculus)
ITPK1 [cytosol]
(Sus scrofa)
ITPK1 [cytosol]
(Xenopus tropicalis)
itpk1b [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_055031.2
,
NP_001136066.1
,
NP_001136065.1
OpenTargets
ENSG00000100605
GeneCards
Q13572
HPA
ENSG00000100605-ITPK1
Ensembl
ENSP00000267615
,
ENSP00000483767
,
ENSG00000274958
,
ENSP00000346272
,
ENST00000614271
,
ENSP00000451091
,
ENST00000556603
,
ENST00000267615
,
ENSP00000480918
,
ENST00000354313
,
ENST00000626153
,
ENSP00000486991
,
ENST00000617836
,
ENSG00000100605
PRO
Q13572
Pharos - Targets
Q13572
HMDB Protein
HMDBP07396
PDB
2ODT
,
2Q7D
,
2QB5
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O95825 QORL1
0.589
2
UniProt:P01848 TRAC
1
TRAC [plasma membrane]
(R-HSA-198175)
0.527
2
UniProt:O60939 SCN2B
1
SCN2B [plasma membrane]
(R-HSA-197905)
0.527
2
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