MARCO:ligand is endocytosed

Stable Identifier
R-HSA-2247510
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane, endocytic vesicle membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MARCO:ligand is endocytosed
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The MARCO:ligand complex is endocytosed (Arredouani et al. 2005, Thelen et al. 2010). In cases where the ligand is part of a bacterial cell the entire cell is phagocytosed.

Literature References
PubMed ID Title Journal Year
20810988 The class A scavenger receptor, macrophage receptor with collagenous structure, is the major phagocytic receptor for Clostridium sordellii expressed by human decidual macrophages

Thelen, T, Hao, Y, Medeiros, AI, Curtis, JL, Serezani, CH, Kobzik, L, Harris, LH, Aronoff, DM

J Immunol 2010
16237101 MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages

Arredouani, MS, Palecanda, A, Koziel, H, Huang, YC, Imrich, A, Sulahian, TH, Ning, YY, Yang, Z, Pikkarainen, T, Sankala, M, Vargas, SO, Takeya, M, Tryggvason, K, Kobzik, L

J Immunol 2005
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
MARCO:ligand is endocytosed (Canis familiaris)
MARCO:ligand is endocytosed (Mus musculus)
MARCO:ligand is endocytosed (Rattus norvegicus)
Authored
Neyen, C  (2013-03-22)
May, B  (2013-01-27)
Reviewed
Neyen, C  (2013-03-22)
Created
May, B  (2012-05-12)