Reactome | Scavenging by Class A Receptors

Scavenging by Class A Receptors

Stable Identifier

R-HSA-3000480

Type

Pathway

Species

Homo sapiens

Compartment

endocytic vesicle membrane, extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this pathway in the Pathway Browser

Class A scavenger receptors contain an intracellular domain, a transmembrane region, a coiled-coil domain, a collagenous domain, and the SR cysteine-rich domain (reviewed in Areschoug and Gordon 2009, Bowdish and Gordon 2009). The coiled coil domains interact to form trimers. The collagenous domain (Rohrer et al. 1990, Acton et al. 1993) and/or the SR cysteine-rich domain (Brannstrom et al. 2002) bind ligands and determine the specificity of the receptor.

Literature References

PubMed ID	Title	Journal	Year
8429029	The collagenous domains of macrophage scavenger receptors and complement component C1q mediate their similar, but not identical, binding specificities for polyanionic ligands Acton, S, Resnick, D, Freeman, M, Ekkel, Y, Ashkenas, J, Krieger, M	J. Biol. Chem.	1993
19388903	Scavenger receptors: role in innate immunity and microbial pathogenesis Areschoug, T, Gordon, S	Cell. Microbiol.	2009
2300208	Coiled-coil fibrous domains mediate ligand binding by macrophage scavenger receptor type II Rohrer, L, Freeman, M, Kodama, T, Penman, M, Krieger, M	Nature	1990
11820786	Arginine residues in domain V have a central role for bacteria-binding activity of macrophage scavenger receptor MARCO Brännström, A, Sankala, M, Tryggvason, K, Pikkarainen, T	Biochem. Biophys. Res. Commun.	2002
19120472	Conserved domains of the class A scavenger receptors: evolution and function Bowdish, DM, Gordon, S	Immunol. Rev.	2009