Alpha-1-Microglobulin is cleaved

Stable Identifier
R-HSA-2203516
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Both hemoglobin and the cytosolic face of erythrocytes are able to catalyze the cleavage of Alpha-1-Microglobulin in the IgA:Alpha-1-Microglobulin complex present in serum (Allhorn et al. 2002). The reaction produces truncated Alpha-1-Microglobulin, which is able to bind and degrade heme. About half of the circulating Alpha-1-Microglobulin is covalently bound to IgA.

Literature References
PubMed ID Title Journal Year
11877257 Processing of the lipocalin alpha(1)-microglobulin by hemoglobin induces heme-binding and heme-degradation properties

Allhorn, M, BerggÄrd, T, Nordberg, J, Olsson, ML, Akerström, B

Blood 2002
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