TIRAP:PI(4,5)P2:BTK:activated TLR2/4 [plasma membrane]

Stable Identifier
Homo sapiens
Related Species
Neisseria meningitidis serogroup B, Chlamydia trachomatis
MAL:PI(4,5)P2:BTK:activated TLR2/4
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
11544529 Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

Jefferies, CA, O'Neill, LA, Mansell, AS, Bird, TA, Brint, E, Smith, DE, Gray, P, Sims, JE, Palsson-McDermott, EM, Bowie, AG, Harte, MT, Fitzgerald, KA, McMurray, D, Dunne, A, Brady, G

Nature 2001
21873236 Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection

Martin, JL, Dimaio, F, Sweet, MJ, Baker, D, Valkov, E, Verstak, B, Kobe, B, Mansell, A, Gay, NJ, Stamp, A, Roversi, P, Kellie, S

Proc. Natl. Acad. Sci. U.S.A. 2011
12724322 Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4

Walch, E, Wietek, C, O'Neill, LA, Brunner, C, Brint, E, Doyle, S, Wirth, T, Dunne, A, Jefferies, CA

J Biol Chem 2003
16439361 MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction

Brikos, C, O'Neill, LA, Gray, P, Doyle, SL, Jefferies, CA, Dunne, A

J Biol Chem 2006
17726518 A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins

Westoll, JF, Brooks, HJ, Wong, J, O'Neill, LA, Núñez Miguel, R, Gay, NJ, Monie, TP, Bryant, CE

PLoS One 2007
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