TIRAP:PI(4,5)P2:BTK:activated TLR2/4

Stable Identifier
R-HSA-2201331
Type
Complex
Species
Homo sapiens
Related Species
Neisseria meningitidis serogroup B, Chlamydia trachomatis
Compartment
Synonyms
MAL:PI(4,5)P2:BTK:activated TLR2/4
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
11544529 Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

Fitzgerald, KA, Palsson-McDermott, EM, Bowie, AG, Jefferies, CA, Mansell, AS, Brady, G, Brint, E, Dunne, A, Gray, P, Harte, MT, McMurray, D, Smith, DE, Sims, JE, Bird, TA, O'Neill, LA

Nature 2001
12724322 Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4

Jefferies, CA, Doyle, S, Brunner, C, Dunne, A, Brint, E, Wietek, C, Walch, E, Wirth, T, O'Neill, LA

J Biol Chem 2003
17726518 A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins

Nez Miguel, R, Wong, J, Westoll, JF, Brooks, HJ, O'Neill, LA, Gay, NJ, Bryant, CE, Monie, TP

PLoS One 2007
21873236 Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection

Valkov, E, Stamp, A, Dimaio, F, Baker, D, Verstak, B, Roversi, P, Kellie, S, Sweet, MJ, Mansell, A, Gay, NJ, Martin, JL, Kobe, B

Proc. Natl. Acad. Sci. U.S.A. 2011
16439361 MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction

Gray, P, Dunne, A, Brikos, C, Jefferies, CA, Doyle, SL, O'Neill, LA

J Biol Chem 2006
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