PMEPA1 sequesters phosphorylated SMAD2/3

Stable Identifier
R-HSA-2187355
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, early endosome membrane
ReviewStatus
5/5
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PMEPA1 sequesters phosphorylated SMAD2/3
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PMEPA1 binds phosphorylated SMAD2 and SMAD3, preventing formation of SMAD2/3:SMAD4 heterotrimers (Watanabe et al. 2010).
Literature References
PubMed ID Title Journal Year
20129061 TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling

Watanabe, Y, Itoh, S, Goto, T, Ohnishi, E, Inamitsu, M, Itoh, F, Satoh, K, Wiercinska, E, Yang, W, Shi, L, Tanaka, A, Nakano, N, Mommaas, AM, Shibuya, H, ten Dijke, P, Kato, M

Mol Cell 2010
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Orthologous Events
PMEPA1 sequesters phosphorylated SMAD2/3 (Bos taurus)
PMEPA1 sequesters phosphorylated SMAD2/3 (Canis familiaris)
PMEPA1 sequesters phosphorylated SMAD2/3 (Gallus gallus)
PMEPA1 sequesters phosphorylated SMAD2/3 (Mus musculus)
PMEPA1 sequesters phosphorylated SMAD2/3 (Rattus norvegicus)
PMEPA1 sequesters phosphorylated SMAD2/3 (Sus scrofa)
PMEPA1 sequesters phosphorylated SMAD2/3 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Created
Orlic-Milacic, M  (2012-04-09)
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