PMEPA1 sequesters phosphorylated SMAD2/3

Stable Identifier
R-HSA-2187355
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
PMEPA1 binds phosphorylated SMAD2 and SMAD3, preventing formation of SMAD2/3:SMAD4 heterotrimers (Watanabe et al. 2010).
Literature References
PubMed ID Title Journal Year
20129061 TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling

Yang, W, Shibuya, H, Itoh, S, Shi, L, Goto, T, Satoh, K, Kato, M, Tanaka, A, Inamitsu, M, Watanabe, Y, Wiercinska, E, ten Dijke, P, Ohnishi, E, Mommaas, AM, Nakano, N, Itoh, F

Mol Cell 2010
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!