PMEPA1 sequesters phosphorylated SMAD2/3

Stable Identifier
R-HSA-2187355
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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PMEPA1 binds phosphorylated SMAD2 and SMAD3, preventing formation of SMAD2/3:SMAD4 heterotrimers (Watanabe et al. 2010).

Literature References
PubMed ID Title Journal Year
20129061 TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling

Watanabe, Y, Itoh, S, Goto, T, Ohnishi, E, Inamitsu, M, Itoh, F, Satoh, K, Wiercinska, E, Yang, W, Shi, L, Tanaka, A, Nakano, N, Mommaas, AM, Shibuya, H, ten Dijke, P, Kato, M

Mol Cell 2010
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created